烟草成分和心理压力对非小细胞肺癌和胰腺癌β-肾上腺素能调控的影响：干预意义。
Effects of tobacco constituents and psychological stress on the beta-adrenergic regulation of non-small cell lung cancer and pancreatic cancer: implications for intervention.
机构信息
Experimental Oncology Laboratory, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, 2407 River Drive Knoxville, TN 37996, USA.
出版信息
Cancer Biomark. 2013;13(3):133-44. doi: 10.3233/CBM-130323.
Abstract
This review summarizes current preclinical and clinical evidence in support of the hypothesis that smoking and psychological stress have significant cancer promoting effects on non small cell lung cancer and pancreatic cancer via direct and indirect effects on nicotinic receptor-regulated beta-adrenergic signaling. Evidence is provided that targeted pharmacological interference with the resulting hyperactive cAMP-dependent signaling by beta-blockers or by γ-aminobutyric acid as well as positive psychological influences may be highly effective in preventing and improving clinical outcomes of these cancers, provided that appropriate diagnostic protocols are followed to monitor systemic levels of stress neurotransmitters and cAMP.
摘要
这篇综述总结了目前支持以下假设的临床前和临床证据
通过直接和间接作用于烟碱型乙酰胆碱受体调节的β-肾上腺素能信号，吸烟和心理压力对非小细胞肺癌和胰腺癌具有显著的促癌作用。有证据表明，通过β受体阻滞剂或γ-氨基丁酸靶向药理学干预由此产生的过度活跃的 cAMP 依赖性信号，以及积极的心理影响，可能在预防和改善这些癌症的临床结果方面非常有效，前提是遵循适当的诊断方案来监测应激神经递质和 cAMP 的系统水平。
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