肾上腺素能受体在肺癌中的作用。
The role of adrenergic receptors in lung cancer.
作者信息
Huang Qi, Tan Qi, Mao Kaimin, Yang Guanghai, Ma Guangzhou, Luo Ping, Wang Sufei, Mei Peiyuan, Wu Feng, Xu Juanjuan, Guo Mengfei, Lv Zhilei, Fan Jinshuo, Zhang Shuai, Wang Xuan, Jin Yang
机构信息
Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Pulmonary Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, China.
Department of Cardiothoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, China.
出版信息
Am J Cancer Res. 2018 Nov 1;8(11):2227-2237. eCollection 2018.
Abstract
Adrenergic receptors (ARs), especially β-ARs, are constitutively expressed in most mammalian cells and are associated with various malignancies including lung cancer. Epidemiologic studies have reported that activation of β-AR signalling promotes the development and progression of lung cancer and that pharmacological interference by β-AR blockers could partially reverse lung cancer progression. In this review, we mainly focus on the role of β-ARs in lung cancer and then reveal the possible application of AR blockers in anti-tumour therapy for lung cancer.
摘要
肾上腺素能受体（ARs），尤其是β-肾上腺素能受体（β-ARs），在大多数哺乳动物细胞中组成性表达，并与包括肺癌在内的各种恶性肿瘤相关。流行病学研究报告称，β-AR信号的激活促进肺癌的发生和发展，而β-AR阻滞剂的药理学干预可部分逆转肺癌进展。在本综述中，我们主要关注β-ARs在肺癌中的作用，然后揭示AR阻滞剂在肺癌抗肿瘤治疗中的可能应用。
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本文引用的文献
1
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
2
Adrenergic Signaling: A Targetable Checkpoint Limiting Development of the Antitumor Immune Response.肾上腺素能信号：限制抗肿瘤免疫反应发展的可靶向检查点。
Front Immunol. 2018 Feb 6;9:164. doi: 10.3389/fimmu.2018.00164. eCollection 2018.
3
Cancer statistics, 2018.癌症统计数据，2018 年。
CA Cancer J Clin. 2018 Jan;68(1):7-30. doi: 10.3322/caac.21442. Epub 2018 Jan 4.
4
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BMC Cancer. 2017 Dec 20;17(1):875. doi: 10.1186/s12885-017-3894-0.
5
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Cancer Immunol Res. 2018 Jan;6(1):98-109. doi: 10.1158/2326-6066.CIR-17-0401. Epub 2017 Nov 16.
6
Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers.应激激素促进 NSCLC 中 EGFR 抑制剂耐药：联合β受体阻滞剂的意义。
Sci Transl Med. 2017 Nov 8;9(415). doi: 10.1126/scitranslmed.aao4307.
7
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8
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J Pathol. 2018 Jan;244(1):49-60. doi: 10.1002/path.4988. Epub 2017 Nov 15.
9
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Cancer Res. 2017 Apr 1;77(7):1611-1622. doi: 10.1158/0008-5472.CAN-16-2143. Epub 2017 Jan 12.
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