Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Cancer Biomark. 2013;13(3):155-60. doi: 10.3233/CBM-130325.
Studies suggest that psychosocial factors can impact cancer progression. Parallel work in the fields of psychoneuroimmunology and developmental neuroscience have led to the implication of catecholamine hormones (norepinephrine and epinephrine) and their receptors (the β-adrenergic receptors; β-ARs) in regulating cancer progression. In this review we discuss studies that describe the effects of psychological stress as mediated by factors including the catecholamines norepinephrine and epinephrine on various aspects of tumor progression including proliferation, angiogenesis, and metastasis. We discuss the role of β-ARs in facilitating these effects and the potential use of β-blockers in adjuvant cancer therapy.
研究表明，社会心理因素会影响癌症的进展。在心理神经免疫学和发展神经科学领域的平行研究表明，儿茶酚胺激素（去甲肾上腺素和肾上腺素）及其受体（β-肾上腺素受体；β-AR）在调节癌症进展中起作用。在这篇综述中，我们讨论了描述儿茶酚胺去甲肾上腺素和肾上腺素等因素通过心理应激介导对肿瘤进展的各个方面（包括增殖、血管生成和转移）的影响的研究。我们讨论了β-AR 促进这些作用的作用以及β-阻滞剂在辅助癌症治疗中的潜在用途。
