Division of Basic Medical Sciences, Kansas City University of Medicine and Biosciences, 1750 Independence Ave., Kansas City, MO, 64106, USA.
Appl Psychophysiol Biofeedback. 2013 Dec;38(4):257-63. doi: 10.1007/s10484-013-9231-8.
To analyze autonomic nervous system activity in headache subjects, measurements of heart rate variability (HRV), skin temperature, skin conductance, and respiration were compared to a matched control group. HRV data were recorded in time and frequency domains. Subjects also completed self-report questionnaires assessing psychological distress, fatigue, and sleep dysfunction. Twenty-one headache and nineteen control subjects participated. In the time domain, the number of consecutive R-to-R intervals that varied by more than 50 ms and the standard deviation of the normalized R-to-R intervals, both indices of parasympathetic nervous system activity, were significantly lower in the headache group than the control group. Groups did not differ statistically on HRV measures in the frequency domain. Self-report measures showed significantly increased somatization, hostility, anxiety, symptom distress, fatigue, and sleep problems in the headache group. The results suggest headache subjects have increased sympathetic nervous system activity and decreased parasympathetic activity compared to non-headache control subjects. Headaches subjects also showed greater emotional distress, fatigue, and sleep problems. The results indicate an association between headaches and cardiovascular functioning suggestive of sympathetic nervous system activation in this sample of mixed migraine and tension-type headache sufferers.
为分析头痛患者自主神经系统活动，将心率变异性（HRV）、皮肤温度、皮肤电导和呼吸测量值与匹配的对照组进行比较。HRV 数据以时间和频率域记录。受试者还完成了自我报告问卷，评估心理困扰、疲劳和睡眠功能障碍。21 名头痛患者和 19 名对照组受试者参与了研究。在时域中，连续 R 到 R 间隔变化超过 50 毫秒的数量和标准化 R 到 R 间隔的标准差，这两个指标均反映副交感神经系统活动，在头痛组显著低于对照组。两组在频域的 HRV 测量值上无统计学差异。自我报告的测量结果表明，头痛组的躯体化、敌意、焦虑、症状困扰、疲劳和睡眠问题显著增加。结果表明，与非头痛对照组相比，头痛患者的交感神经系统活动增加，副交感神经系统活动减少。头痛患者还表现出更大的情绪困扰、疲劳和睡眠问题。结果表明，头痛与心血管功能之间存在关联，提示该混合偏头痛和紧张型头痛患者样本中存在交感神经系统激活。
