Monteiro Isabel Oliveira, Novakovic Juliana, Rodrigues Miguel K, Cunha Neto Joel S, Rela Maíra O V, Oliveira Mayron F
Universidade de Fortaleza, Centro de Ciências da Saúde, Curso de Fisioterapia, Fortaleza CE, Brazil.
Lyon College, Exercise Science Department, Exercise Physiology and Integrated Cardiopulmonary Research Group, Batesville AR, United States.
Arq Neuropsiquiatr. 2025 May;83(5):1-8. doi: 10.1055/s-0045-1808085. Epub 2025 Jun 17.
Migraine causes intense pain, significant disability, deficits in attention and memory, slowed information processing, and cognitive disorders. However, it is unclear how migraine, cardiovascular, and cerebral issues impact daily life or relate to future adverse events.To evaluate the brain activity and autonomic regulation in untreated migraine patients.In the present case-control study, we compared untreated migraine patients with healthy controls. The participants underwent cognitive testing (Stroop Color Test, Trail Making Test, Addenbrooke's Cognitive Examination, and Reaction Time Test), brain activity measurement (MindWave Mobile), and autonomic regulation assessment via heart rate variability (Polar V800).No differences were found between the groups in terms of cognitive test scores. However, the healthy controls consistently showed increased variation in brain activity during the cognitive tests, while migraine patients exhibited decreased activity across all tests ( < 0.05). During the Stroop Color Test, the controls showed a positive change in brain activity (Δ = 5.12 ± 3.64) while the migraine patients showed a negative change (Δ = -5.41 ± 2.21). In addition, the control group demonstrated a normal autonomic response, with increased sympathetic activity (low-frequency [LF] band: 70.2-84.4 Hz) and decreased parasympathetic activity (high-frequency [HF] band: 29.6-15.6 Hz) during cognitive tasks ( < 0.05). In contrast, the migraine group showed imbalanced autonomic regulation, characterized by minimal changes in both sympathetic (LF band: 74.0-74.8 Hz) and parasympathetic activity (HF band: 25.9-25.1 Hz) ( > 0.05).Despite the similar cognitive test scores, migraine patients exhibited reduced variation in brain activity during cognitive tests and an imbalanced autonomic regulation, characterized by decreased sympathetic activity and increased parasympathetic activity.
偏头痛会导致剧烈疼痛、严重残疾、注意力和记忆力缺陷、信息处理速度减慢以及认知障碍。然而，偏头痛、心血管和脑部问题如何影响日常生活或与未来不良事件相关尚不清楚。为了评估未经治疗的偏头痛患者的大脑活动和自主调节功能。在本病例对照研究中，我们将未经治疗的偏头痛患者与健康对照者进行了比较。参与者接受了认知测试（斯特鲁普颜色测试、连线测验、Addenbrooke认知检查和反应时间测试）、大脑活动测量（MindWave Mobile）以及通过心率变异性进行的自主调节评估（Polar V800）。两组在认知测试分数方面没有差异。然而，健康对照者在认知测试期间大脑活动的变化始终增加，而偏头痛患者在所有测试中活动均减少（<0.05）。在斯特鲁普颜色测试中，对照者大脑活动呈正向变化（Δ=5.12±3.64），而偏头痛患者呈负向变化（Δ=-5.41±2.21）。此外，对照组表现出正常的自主反应，在认知任务期间交感神经活动增加（低频[LF]波段：70.2 - 84.4赫兹），副交感神经活动减少（高频[HF]波段：29.6 - 15.6赫兹）（<0.05）。相比之下，偏头痛组表现出自主调节失衡，其特征是交感神经（LF波段：74.0 - 74.8赫兹）和副交感神经活动（HF波段：25.9 - 25.1赫兹）变化均极小（>0.05）。尽管认知测试分数相似，但偏头痛患者在认知测试期间大脑活动变化减少，且自主调节失衡，表现为交感神经活动减少和副交感神经活动增加。
