Chen Hao, Li Ming-Hua
Institute of Diagnostic and Interventional Radiology, The Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, 600 Yi Shan Road, 200233, ShangHai, China,
Surg Radiol Anat. 2014 May;36(4):353-7. doi: 10.1007/s00276-013-1182-5. Epub 2013 Aug 4.
This study is to evaluate the use of three-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) at 3.0 T for the detection and classification of A1 segment hypoplasia based on a large case series and investigates the potential links with AcomA aneurysm occurrence.
Between January 2009 and June 2012, 8,013 patients underwent MRA examination at 3.0 T in our hospital. MRA was performed using 3D-TOF with volume rendering technique. The presence and location of A1 segment hypoplasia and AcomA aneurysm was reviewed.
Among the 8,013 patients examined, 138 patients were identified with AcomA aneurysms. 425 patients were defined with A1 segment hypoplasia, among whom 303 right-sided A1 hypoplasia and 122 left-sided A1 hypoplasia. 60 of these 425 patients were confirmed with AcomA aneurysms, among them were 49 right-sided A1 hypoplasia. The prevalence of AcomA aneurysm with A1 segment hypoplasia was 14.1 %, which was much higher compared with that (1.0 %) of AcomA aneurysm without A1 segment hypoplasia (P < 0.001).
The incidence of right-sided A1 segment hypoplasia either accompanied with AcomA aneurysm or not was much greater than that of left-sided. Intracranial AcomA aneurysm development appeared to be associated with A1 segment hypoplasia.
本研究旨在基于一个大型病例系列，评估3.0 T场强下的三维时间飞跃磁共振血管造影（3D-TOF MRA）用于检测A1段发育不全并对其进行分类，并研究其与前交通动脉瘤（AcomA动脉瘤）发生的潜在关联。
2009年1月至2012年6月期间，我院8013例患者接受了3.0 T场强的MRA检查。采用3D-TOF及容积再现技术进行MRA检查。回顾性分析A1段发育不全及AcomA动脉瘤的存在情况及位置。
在8013例接受检查的患者中，138例被诊断为AcomA动脉瘤。425例被定义为A1段发育不全，其中右侧A1段发育不全303例，左侧A1段发育不全122例。这425例患者中有60例被确诊为AcomA动脉瘤，其中右侧A1段发育不全49例。A1段发育不全的患者中AcomA动脉瘤的患病率为14.1%，与无A1段发育不全的患者中AcomA动脉瘤的患病率（1.0%）相比显著更高（P<0.001）。
无论是否伴有AcomA动脉瘤，右侧A1段发育不全的发生率均远高于左侧。颅内AcomA动脉瘤的发生似乎与A1段发育不全有关。
