血清瘦素对非ST段抬高型急性冠脉综合征患者冠状动脉侧支循环发育无影响：一项观察性研究。

Serum leptin has no effect on coronary collateral development in patients with non-ST-elevation acute coronary syndromes: an observational study.

作者信息

Günebakmaz Ozgür, Duran Mustafa, Akpek Mahmut, Zencir Cemil, Elcik Deniz, Oğuzhan Abdurrahman, Kaya Mehmet Güngör

机构信息

Department of Cardiology, Faculty of Medicine, Erciyes University, Kayseri-Turkey.

出版信息

Anadolu Kardiyol Derg. 2013 Nov;13(7):655-61. doi: 10.5152/akd.2013.187. Epub 2013 Jul 31.

DOI:10.5152/akd.2013.187

PMID:23912787

Abstract

OBJECTIVE

We attempted to investigate the potential association between leptin and coronary collateral vessel development in patients with non-ST elevation acute coronary syndromes (NSTE-ACS).

METHODS

One hundred and nineteen consecutive patients with NSTE-ACS with high-grade coronary stenosis or occlusion in at least one epicardial coronary artery were prospectively enrolled in a cross-sectional observational study. Serum leptin levels measured in all patients. Collateral circulation was graded according to the Rentrop classification. Firstly, we divided patients into two groups as good and poor collateral group. Patients with Rentrop 2.3 were regarded as good collateral group. Patients in Rentrop grades 0, 1 classified as poor collateral group. Secondly, patients were divided into collateral (+) group and collateral (-) group. Collateral (+) group included the patients with grade 1, 2, 3 collateral development. Collateral (-) group was composed of the patients with Rentrop 0. Statistical analysis was performed using Student t-test, Mann-Whitney U test, Chi-square test, Kruskal -Wallis test and Spearman's correlation.

RESULTS

We did not find statistically significant difference between good and poor collateral groups with regard to leptin levels [4.2 (1.8-8.6) ng/mL and 6.4 (2.4-12.6) ng/mL, p=0.22, respectively]. There was no statistically significant difference in leptin levels between collateral (+) group and collateral (-) groups [4.7 (1.7-10.5) ng/mL and 6.8 (2.7-12.1) ng/mL, p=0.33, respectively]. We observed that there was lower leptin level at higher Rentrop grades [Rentrop 0; 6.8 (2.5-12.5) ng/mL, Rentrop 1; 5.9 (1.7-14.1) ng/mL, Rentrop 2; 4.3 (1.7-8.7) ng/mL, Rentrop 3; 3.9 (2.1-9.7) ng/mL]. However, this difference did not reach statistically significant level (p=0.54). In addition, we did not find statistically significant correlation between Rentrop grades and leptin levels (p=0.246, r=-0.107).

CONCLUSION

The present study reveals no association between serum leptin level and coronary collateral development.

摘要

目的

我们试图研究瘦素与非ST段抬高型急性冠状动脉综合征（NSTE-ACS）患者冠状动脉侧支血管发育之间的潜在关联。

方法

119例至少有一支心外膜冠状动脉存在高度狭窄或闭塞的NSTE-ACS连续患者被前瞻性纳入一项横断面观察性研究。测量所有患者的血清瘦素水平。根据Rentrop分级对侧支循环进行分级。首先，我们将患者分为两组，即侧支良好组和侧支不良组。Rentrop分级为2、3级的患者被视为侧支良好组。Rentrop分级为0、1级的患者被归类为侧支不良组。其次，将患者分为侧支（+）组和侧支（-）组。侧支（+）组包括侧支发育为1、2、3级的患者。侧支（-）组由Rentrop分级为0级的患者组成。采用学生t检验、曼-惠特尼U检验、卡方检验、克鲁斯卡尔-沃利斯检验和斯皮尔曼相关性分析进行统计分析。

结果

我们发现侧支良好组和侧支不良组之间的瘦素水平无统计学显著差异[分别为4.2（1.8 - 8.6）ng/mL和6.4（2.4 - 12.6）ng/mL，p = 0.22]。侧支（+）组和侧支（-）组之间的瘦素水平也无统计学显著差异[分别为4.7（1.7 - 10.5）ng/mL和6.8（2.7 - 12.1）ng/mL，p = 0.33]。我们观察到Rentrop分级越高，瘦素水平越低[Rentrop 0级；6.8（2.5 - 12.5）ng/mL，Rentrop 1级；5.9（1.7 - 14.1）ng/mL，Rentrop 2级；4.3（1.7 - 8.7）ng/mL，Rentrop 3级；3.9（2.1 - 9.7）ng/mL]。然而，这种差异未达到统计学显著水平（p = 0.54）。此外，我们未发现Rentrop分级与瘦素水平之间存在统计学显著相关性（p = 0.246，r = -0.107）。