神经发育和疾病中的胞嘧啶修饰。
Cytosine modifications in neurodevelopment and diseases.
机构信息
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA.
出版信息
Cell Mol Life Sci. 2014 Feb;71(3):405-18. doi: 10.1007/s00018-013-1433-y. Epub 2013 Aug 3.
Abstract
DNA methylation has been studied comprehensively and linked to both normal neurodevelopment and neurological diseases. The recent identification of several new DNA modifications, including 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, has given us a new perspective on the previously observed plasticity in 5mC-dependent regulatory processes. Here, we review the latest research into these cytosine modifications, focusing mainly on their roles in neurodevelopment and diseases.
摘要
DNA 甲基化已得到全面研究，并与正常神经发育和神经疾病相关联。最近鉴定出几种新的 DNA 修饰，包括 5-羟甲基胞嘧啶、5-甲酰胞嘧啶和 5-羧基胞嘧啶，为我们提供了一个新的视角，即以前在 5mC 依赖的调节过程中观察到的可塑性。在这里，我们综述了这些胞嘧啶修饰的最新研究，主要集中在它们在神经发育和疾病中的作用。
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