First Department of Cardiology, Athens Medical School, Hippokration Hospital, Athens, Greece.
Hellenic J Cardiol. 2013 Jul-Aug;54(4):318-21.
Renal artery denervation has recently emerged as a novel therapy for patients with resistant hypertension. Clinical results from renal sympathetic denervation support the safety and efficacy of this method over a period of 18 months. However, several limitations have been reported. Previous studies have shown that chemical denervation by vincristine is safe and effective in an experimental model. We describe the first-in-man application of chemical denervation with vincristine in a 74-year-old male patient with resistant arterial hypertension.
肾动脉去神经支配术最近作为一种治疗难治性高血压的新方法出现。肾交感神经去神经支配术的临床结果支持该方法在 18 个月内的安全性和有效性。然而，已经报道了一些局限性。先前的研究表明，长春新碱的化学去神经支配在实验模型中是安全有效的。我们描述了首例长春新碱化学去神经支配在一名 74 岁男性难治性动脉高血压患者中的应用。
