White Jonathon M, Veale Andrew G, Ruygrok Peter N
Green Lane Cardiovascular Service, Level 3, Auckland City Hospital, Private Bag 92024, Auckland 1030, New Zealand.
J Invasive Cardiol. 2013 Aug;25(8):E169-71.
Obstructive sleep apnea (OSA) and patent foramen ovale (PFO) are common conditions and may coexist. In patients with OSA, increases in right-to-left shunting across a PFO may result in increased burden of hypoxia, although the effect of this is unknown. We report the cases of 3 patients with highly symptomatic OSA and PFO who underwent percutaneous closure with the Coherex FlatStent PFO Closure System. Although PFO closure can be achieved with minimally invasive techniques and low rates of adverse events, its importance in reducing hypoxia in this population is unknown. PFO closure may result in improvement in apneas and symptoms in selected OSA patients and may impact cardiovascular events in this group through hypoxia-mediated or other unrecognized mechanisms.
阻塞性睡眠呼吸暂停（OSA）和卵圆孔未闭（PFO）是常见病症，且可能同时存在。在OSA患者中，经卵圆孔未闭的右向左分流增加可能导致缺氧负担加重，尽管其影响尚不清楚。我们报告了3例症状严重的OSA合并PFO患者的病例，这些患者接受了使用Coherex FlatStent PFO封堵系统的经皮封堵术。尽管PFO封堵可以通过微创技术实现且不良事件发生率较低，但其在减轻该人群缺氧方面的重要性尚不清楚。PFO封堵可能会使部分OSA患者的呼吸暂停和症状得到改善，并可能通过缺氧介导或其他未被认识的机制影响该组患者的心血管事件。
