Li Vincent, Chang Andy Y, Williams Travis J
Loker Hydrocarbon Research Institute, Department of Chemistry, University of Southern California, 837 Bloom Walk, Los Angeles, CA 90089-1661, USA.
Tetrahedron. 2013 Sep 9;69(36):7741-7746. doi: 10.1016/j.tet.2013.05.092.
Gadolinium-containing phosphonate-coated gold nanoparticles were prepared and then non-covalently coated with an amphiphilic fluorous monomer. The monomer spontaneously self-assembles into a non-covalent monolayer shell around the particle. The binding of the shell utilizes a guanidinium-phosphonate interaction analogous to the one exploited by the Wender molecular transporter system. Particle-shell binding was characterized by a 27% decrease in F T of the fluorous shell upon exposure to the paramagnetic gadolinium in the particle and a corresponding increase in hydrodynamic diameter from 3 nm to 4 nm. Interestingly, a much smaller modulation of F T is observed when the shell monomer is treated with a phosphonate-free particle. By contrast, the phosphonate-free particle is a much more relaxive H T agent for water. Together, these observations show that the fluoroalkylguanidinium shell binds selectively to the phosphonate-covered particle. The system's relaxivity and selectivity give it potential for use in F based nanotheranostic agents.
制备了含钆的膦酸盐包覆的金纳米颗粒，然后用两亲性含氟单体进行非共价包覆。该单体围绕颗粒自发地自组装成非共价单层壳。壳的结合利用了类似于温德分子转运系统所利用的胍基 - 膦酸盐相互作用。颗粒 - 壳结合的特征是，当氟碳壳暴露于颗粒中的顺磁性钆时，氟碳壳的FT降低27%，同时流体动力学直径从3nm相应增加到4nm。有趣的是，当壳单体用不含膦酸盐的颗粒处理时，观察到FT的调制要小得多。相比之下，不含膦酸盐的颗粒对水来说是一种弛豫性更强的HT剂。这些观察结果共同表明，氟代烷基胍壳选择性地结合到膦酸盐覆盖的颗粒上。该系统的弛豫率和选择性使其有潜力用于基于F的纳米诊疗剂。
