Dauprat P, Dalle M, Delost P
Laboratoire de Physiologie Animale, Universite Blaise Pascal, Clermont-Ferrant II, Aubière, France.
J Dev Physiol. 1990 Jan;13(1):13-6.
The maternal metabolic clearance rate (MCR) and the binding of cortisol in the plasma of fetus and mother were estimated 8 days before term in conscious pregnant guinea-pigs, control or subjected to a neurotrophic stress (they were immobilized for 3 h in a dark room in front of an intermittent luminous flash). The maternal MCR of cortisol dropped during pregnancy related to an increase in corticosteroid binding globulin (CBG) and the stress mimicked these changes with a decrease in MCR and a rise in CBG. The increase in cortisol concentrations occurring in the fetal plasma after maternal stress could be related to the increase in free cortisol in the stressed mother. Nevertheless, although the fetal CBG did not rise after maternal stress, the increase in free cortisol in the fetal plasma remained moderate, due to the numerous free sites of CBG and albumin for cortisol.
在足月前8天，对清醒的妊娠豚鼠（对照组或遭受神经营养应激，即被固定在暗室中，在间歇性闪光前3小时），估计母体代谢清除率（MCR）以及胎儿和母体血浆中皮质醇的结合情况。孕期母体皮质醇的MCR下降，这与皮质类固醇结合球蛋白（CBG）增加有关，而应激模拟了这些变化，MCR降低且CBG升高。母体应激后胎儿血浆中皮质醇浓度的增加可能与应激母体中游离皮质醇的增加有关。然而，尽管母体应激后胎儿CBG没有升高，但由于CBG和白蛋白有大量可结合皮质醇的游离位点，胎儿血浆中游离皮质醇的增加仍保持在适度水平。
