Rosenberg Shilo, Katz Ran, Pode Dov, Gofrit N Ofer, Pizov Galina, Hovav Nechushtan
Department of Urology, Hadassah-Hebrew University Medical Center Jerusalem, Israel.
Can Urol Assoc J. 2013 Jul-Aug;7(7-8):E490-4. doi: 10.5489/cuaj.172.
We describe an unusual presentation of metastatic lung adenocarcinoma as malignant retroperitoneal fibrosis (MRPF). The diagnostic challenge, due to the small solitary lung mass and absence of a discrete retroperitoneal mass, was overcome by diagnostic laparoscopy. Molecular analysis of tissue acquired was positive for ALK gene rearrangement. Treatment of the patient with crizotinib reversed MRPF. He was weaned off the nephrostomy tubes and is with stable renal function 11 months after diagnosis.
我们描述了一例转移性肺腺癌表现为恶性腹膜后纤维化（MRPF）的不寻常病例。由于肺部存在孤立性小肿块且腹膜后无明显肿块，诊断面临挑战，而诊断性腹腔镜检查克服了这一难题。对获取的组织进行分子分析显示ALK基因重排呈阳性。使用克唑替尼治疗该患者后，MRPF得到缓解。患者停用了肾造瘘管，诊断后11个月肾功能稳定。
