地菍中的类胡萝卜素作为潜在的抗炎药。

Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents.

机构信息

Department of Natural Products, National Institute of Pharmaceutical Education and Research-NIPER, Sector-67, SAS Nagar-Mohali-160062, Punjab, India.

出版信息

J Nat Prod. 2013 Aug 23;76(8):1393-8. doi: 10.1021/np300899w. Epub 2013 Aug 5.

DOI:10.1021/np300899w

PMID:23914900

Abstract

Five new (2, 3, 5, 7, and 9) and four known rotenoids (1, 4, 6, and 8) were isolated from a methanol extract of Boerhaavia diffusa roots. The structures of the new rotenoids were elucidated by spectroscopic data interpretation. The 70% ethanol extract, a rotenoid-rich fraction, and all isolated rotenoids were evaluated for their COX-1 and COX-2 inhibitory activities. Among the rotenoids tested, compound 7 showed the most potent COX-1 and COX-2 inhibition, with IC₅₀ values of 21.7 ± 0.5 and 25.5 ± 0.6 μM, respectively. Boeravinone B (6) exhibited significant anti-inflammatory activity (56.6% at 50 mg/kg) when evaluated in an in vivo carrageenan-induced rat paw model.

摘要

从白花丹根的甲醇提取物中分离得到了 5 个新的（2、3、5、7 和 9）和 4 个已知的鱼藤酮类化合物（1、4、6 和 8）。通过光谱数据分析阐明了新鱼藤酮类化合物的结构。评估了 70%乙醇提取物、富含鱼藤酮的部分以及所有分离得到的鱼藤酮类化合物对 COX-1 和 COX-2 的抑制活性。在所测试的鱼藤酮类化合物中，化合物 7 对 COX-1 和 COX-2 的抑制作用最强，IC₅₀ 值分别为 21.7 ± 0.5 和 25.5 ± 0.6 μM。在体内角叉菜胶诱导的大鼠足爪模型中评估时，Boeravinone B（6）表现出显著的抗炎活性（50 mg/kg 时为 56.6%）。