Department of Biotechnology, Sri Venkateswara College of Engineering, Sriperumbudur Tk - 602117, Tamilnadu, India.
Mini Rev Med Chem. 2021;21(13):1734-1746. doi: 10.2174/1389557521666210217092634.
Phytochemicals play a vital role as drugs for the treatment of various autoimmune, viral, and cancerous diseases. Rotenoids, a type of isoflavone compounds present in plants genus Boerhaavia sp., Mirabilis sp. and Abronia sp. which belong to the Nyctaginaceae family, are traditionally used as pesticides and insecticides. Boeravinones are groups of rotenoid compounds widely used as drugs or drug adjuvants for the treatment of various diseases. Extraction of rotenoids in various solvents, purification of rotenoids in various chromatographic technique studies, and the characterization of functional groups of rotenoids in various spectroscopic techniques have been reported. Biological applications of rotenoids such as anti-cancerous, antioxidant, anti-inflammatory, antimicrobial, and cytotoxic activities have been discussed. This review summarizes the extraction, isolation, purification, and characterization of rotenoid compounds and their effect on the treatment of cancer, inflammatory, spasmolytic, autoimmune, and microbial diseases.
植物化学物质作为治疗各种自身免疫、病毒和癌症疾病的药物起着至关重要的作用。类异黄酮化合物是植物属 Boerhaavia sp.、Mirabilis sp. 和 Abronia sp. 中的一种，属于Nyctaginaceae 科，它们被传统上用作杀虫剂和杀虫剂。Boeravinones 是广泛用作治疗各种疾病的药物或药物佐剂的类鱼藤酮化合物。已经报道了各种溶剂中类鱼藤酮的提取、各种色谱技术中类鱼藤酮的纯化以及各种光谱技术中类鱼藤酮官能团的表征。已经讨论了类鱼藤酮的生物学应用，如抗癌、抗氧化、抗炎、抗菌和细胞毒性活性。本综述总结了类鱼藤酮化合物的提取、分离、纯化和表征及其在治疗癌症、炎症、痉挛、自身免疫和微生物疾病方面的作用。
