金莲花属植物中的三萜皂苷及其潜在的抗炎活性。
Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing, People's Republic of China.
出版信息
J Nat Prod. 2010 Jul 23;73(7):1234-9. doi: 10.1021/np100057y.
PMID:20540535
Abstract
Seven new triterpene saponins, clematochinenosides A-G (1-7), together with 17 known saponins (8-24), were isolated from the roots and rhizomes of Clematis chinensis. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. Compounds 1, 3-7, and 20-24 showed inhibitory activities against COX-1 and COX-2 enzymes.
摘要
从中国铁线莲的根和根茎中分离得到了 7 种新的三萜皂苷，分别命名为 clematochinenosides A-G（1-7），以及 17 种已知的皂苷（8-24）。基于光谱证据和水解产物，鉴定了它们的结构。化合物 1、3-7 和 20-24 对 COX-1 和 COX-2 酶表现出抑制活性。
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