Focas Research Institute, Dublin Institute of Technology, Camden Row, Dublin 8, Ireland.
Nanomedicine (Lond). 2013 Aug;8(8):1335-51. doi: 10.2217/nnm.13.108.
Raman spectroscopy is a branch of vibration spectroscopy that is capable of probing the chemical composition of materials. Recent advances in Raman microscopy have significantly added to the range of applications, which now extend from medical diagnostics to exploring the interfaces between biological organisms and nanomaterials. In this review, Raman is introduced in a general context, highlighting some of the areas in which the technique has been successful in the past, as well as some of the potential benefits it offers over other analytical modalities. The subset of Raman techniques that specifically probe the nanoscale, namely surface- and tip-enhanced Raman spectroscopy, will be described and specific applications relevant to nanomedical applications will be reviewed. Progress in the use of traditional label-free Raman for investigation of nanoscale interactions will be described, and recent developments in coherent anti-Stokes Raman scattering will be explored, particularly its applications to biomedical and nanomedical fields.
拉曼光谱是振动光谱学的一个分支，能够探测材料的化学成分。拉曼显微镜的最新进展极大地扩展了应用范围，现在从医学诊断扩展到探索生物有机体和纳米材料之间的界面。在这篇综述中，拉曼光谱在一般背景下进行介绍，强调了该技术过去在哪些领域取得了成功，以及它相对于其他分析模式提供的一些潜在优势。将描述专门探测纳米尺度的拉曼技术子集，即表面和尖端增强拉曼光谱，并回顾与纳米医学应用相关的特定应用。将描述传统无标记拉曼用于研究纳米尺度相互作用的进展，并探讨相干反斯托克斯拉曼散射的最新进展，特别是它在生物医学和纳米医学领域的应用。
