Goto T, Kuzuya F, Endo H, Tajima T, Ikari H
Department of Geriatrics, Nagoya University School of Medicine, Japan.
J Neural Transm Suppl. 1990;30:1-11. doi: 10.1007/978-3-7091-3345-3_1.
The aim of this study is to observe the relationship between the impairment in passive avoidance task induced in rats by the i.p. administration of muscarinic antagonists, scopolamine and methyl-scopolamine, and the change in acetylcholine (ACh) output induced by these drugs. Initially we studied the effects of these drugs on the animals' performance of a step-through passive avoidance task. We then measured the change in ACh levels after administration of these drugs using an in vivo brain dialysis technique. Scopolamine was effective in impairing the performance of the passive avoidance task, while methyl-scopolamine did not have clear effects on the performance of the task. With regard to ACh output, scopolamine increased ACh dose-dependently and methyl-scopolamine also affected ACh release. These data suggest that the accumulation of ACh in the synaptic cleft may be involved in the memory deficit induced by scopolamine.
本研究的目的是观察腹腔注射毒蕈碱拮抗剂东莨菪碱和甲基东莨菪碱诱导大鼠被动回避任务损伤与这些药物诱导的乙酰胆碱（ACh）释放变化之间的关系。最初，我们研究了这些药物对动物进行穿梭式被动回避任务表现的影响。然后，我们使用体内脑透析技术测量了这些药物给药后ACh水平的变化。东莨菪碱能有效损害被动回避任务的表现，而甲基东莨菪碱对该任务的表现没有明显影响。关于ACh释放，东莨菪碱剂量依赖性地增加ACh释放，甲基东莨菪碱也影响ACh释放。这些数据表明，突触间隙中ACh的积累可能与东莨菪碱诱导的记忆缺陷有关。
