Allergy Unit, G. da Saliceto Hospital, Piacenza, Italy.
Allergy. 2013 Sep;68(9):1193-5. doi: 10.1111/all.12198. Epub 2013 Aug 6.
Sublingual immunotherapy (SLIT) is often discontinued, and many patients do not renew the prescription. We evaluated the reasons for discontinuation and set up an educational/follow-up plan to improve the adherence. In a first phase, the adherence at 4 months was directly assessed. Based on those results, an action plan (education, frequent contacts, and strictly scheduled visits) was developed and tested in other patients. A group of matched patients did not undergo the follow-up plan (controls). In the first phase, involving 252 subjects, at 4 months, there were 30% dropouts, mainly due to side-effects. In the second phase, 149 patients underwent education/follow-up and 90 received no intervention. In the first group, discontinuations at 4 months were 5%, vs 18% in the controls (P = 0.01). After one year, 12% of patients were lost in the first group and 35% in the control group (P < 0.001). An adequate education and a strict follow-up can significantly reduce SLIT's discontinuations.
舌下免疫疗法（SLIT）常被中断，许多患者不再续方。我们评估了中断的原因，并制定了教育/随访计划以提高依从性。在第一阶段，直接评估了 4 个月时的依从性。基于这些结果，制定了行动计划（教育、频繁联系和严格预约就诊）并在其他患者中进行了测试。一组匹配的患者未接受随访计划（对照组）。在第一阶段，涉及 252 名患者，在 4 个月时，有 30%的患者脱落，主要是由于副作用。在第二阶段，149 名患者接受了教育/随访，90 名患者未接受干预。在第一组中，4 个月时的停药率为 5%，而对照组为 18%（P = 0.01）。一年后，第一组中有 12%的患者失访，对照组中有 35%的患者失访（P < 0.001）。充分的教育和严格的随访可以显著减少 SLIT 的中断。
