基于（CuInSe(x)S(2-x))/ZnS 核/壳量子点的微粒型口服疫苗的活体动物整体荧光成像。
In vivo whole animal fluorescence imaging of a microparticle-based oral vaccine containing (CuInSe(x)S(2-x))/ZnS core/shell quantum dots.
机构信息
Department of Chemical Engineering, Texas Materials Institute, and Center for Nano- and Molecular Science and Technology, The University of Texas at Austin , Austin, Texas 78712, United States.
出版信息
Nano Lett. 2013 Sep 11;13(9):4294-8. doi: 10.1021/nl402054w. Epub 2013 Aug 9.
Abstract
Zinc sulfide-coated copper indium sulfur selenide (CuInSexS2-x/ZnS core/shell) nanocrystals were synthesized with size-tunable red to near-infrared (NIR) fluorescence with high quantum yield (40%) in water. These nanocrystals were tested as an imaging agent to track a microparticle-based oral vaccine administered to mice. Poly(lactic-co-glycolic acid) (PLGA) microparticle-encapsulated CuInSexSe2-x/ZnS quantum dots were orally administered to mice and were found to provide a distinct visible fluorescent marker in the gastrointestinal tract of living mice.
摘要
硫化锌包覆的铜铟硫硒（CuInSexS2-x/ZnS 核/壳）纳米晶体具有可调谐的尺寸、从红色到近红外（NIR）的荧光，并且在水中具有高量子产率（40%）。这些纳米晶体被用作成像剂来跟踪递送给小鼠的基于微粒的口服疫苗。聚（乳酸-共-乙醇酸）（PLGA）微粒包封的 CuInSexSe2-x/ZnS 量子点被口服给予小鼠，并在活体小鼠的胃肠道中提供了明显的可见荧光标记。
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