偏头痛患者内源性抑郁的高发病率：通过酪胺试验证实。
High incidence of endogenous depression in migraine: confirmation by tyramine test.
作者信息
Jarman J, Fernandez M, Davies P T, Glover V, Steiner T J, Thompson C, Rose F C, Sandler M
机构信息
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, United Kingdom.
出版信息
J Neurol Neurosurg Psychiatry. 1990 Jul;53(7):573-5. doi: 10.1136/jnnp.53.7.573.
Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migraine group as a whole had significantly low values compared with 14 normal controls, due almost entirely to low values in the endogenous depressive subgroup; there were no differences between diet-sensitive and non-diet-sensitive migraine patients. Thus depression in patients with migraine seems unlikely to be secondary to migraine per se. A substantial subgroup of patients with migraine may possess an inherent predisposition to endogenous depression.
对40名在专科门诊就诊的偏头痛患者进行了《情感障碍和精神分裂症日程表——终身版》访谈。根据研究诊断标准，16名（40%）患者有重度抑郁症病史，其中15名属于内源性类型。酪胺试验是一种先前确立的内源性抑郁症特质标志物，结果显示，与14名正常对照者相比，偏头痛组总体数值显著偏低，几乎完全是由于内源性抑郁亚组数值偏低所致；饮食敏感型和非饮食敏感型偏头痛患者之间没有差异。因此，偏头痛患者的抑郁症似乎不太可能继发于偏头痛本身。相当一部分偏头痛患者可能具有内源性抑郁症的内在易感性。
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