Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA; Immunology and Molecular Pathogenesis Program, Emory University, Atlanta, GA.
Am J Transplant. 2013 Sep;13(9):2245-54. doi: 10.1111/ajt.12380. Epub 2013 Aug 5.
Osteoimmunology is a field of research dedicated to the study of the interactions between the immune system, the hemopoietic system and bone. Among the cells of the immune system that regulate bone cells and the hemopoietic function are T lymphocytes. These cells secrete inflammatory cytokines that promote bone resorption, as well as Wnt ligands that stimulate bone formation. In addition, T cells regulate bone homeostasis by cross talking with BM stromal cells and osteoblastic cells via CD40 ligand (CD40L) and other costimulatory molecules. This article describes the immune cells relevant to bone and the hemopoietic function, reviews the role of lymphocytes as mediators of the effects of PTH and estrogen in bone and the hemopoietic system and discusses the implication of osteoimmunology for transplant medicine.
骨免疫学是一个致力于研究免疫系统、造血系统和骨骼之间相互作用的研究领域。在调节骨细胞和造血功能的免疫系统细胞中，T 淋巴细胞是其中之一。这些细胞分泌炎症细胞因子，促进骨质吸收，同时分泌 Wnt 配体，刺激骨形成。此外，T 细胞通过与 BM 基质细胞和成骨细胞的 CD40 配体（CD40L）和其他共刺激分子的相互作用来调节骨稳态。本文描述了与骨骼和造血功能相关的免疫细胞，综述了淋巴细胞作为甲状旁腺激素和雌激素在骨骼和造血系统中作用的介质的作用，并讨论了骨免疫学对移植医学的意义。
