T 细胞在甲状旁腺激素作用调节中的作用：生理和临床意义。
Role of T cells in the modulation of PTH action: physiological and clinical significance.
机构信息
Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, Room 1309, Atlanta, GA, 30322, USA,
出版信息
Endocrine. 2013 Dec;44(3):576-82. doi: 10.1007/s12020-013-9960-8. Epub 2013 Jun 2.
Abstract
Osteoimmunology is new field of research dedicated to the study of the interactions between the immune system and bone. Among the cells of the immune system that regulate bone and hemopoietic cells are T lymphocytes. These cells secrete osteoclastogenic cytokines such as RANKL and TNF, as well as factors that stimulate bone formation and hemopoietic cells, one of which is Wnt10b. This article will review the evidence that T cells are implicated in the mechanism of action of parathyroid hormone (PTH) in bone and on the hemopoietic system.
摘要
骨免疫学是一个致力于研究免疫系统和骨骼之间相互作用的新领域。在调节骨骼和造血细胞的免疫系统细胞中，T 淋巴细胞是其中之一。这些细胞分泌破骨细胞生成细胞因子，如 RANKL 和 TNF，以及刺激骨形成和造血细胞的因子，其中之一是 Wnt10b。本文将综述 T 细胞参与甲状旁腺激素（PTH）在骨骼和造血系统中作用机制的证据。
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