Double J C, Brown J R
J Pharm Pharmacol. 1975 Jul;27(7):502-7. doi: 10.1111/j.2042-7158.1975.tb09492.x.
A series of aminoalkylaminoanthraquinones have been prepared as potential intercalating agents. The binding to DNA of these compounds and the known intercalating drugs chloroquine, lucanthone, daunorubicin and doxorubicin has been characterized by spectrophotometric titration. The association constant for the interaction with DNA has been determined for each compound from a Scatchard plot. The compounds synthesized had association constants between 0-5 and 4-2 times 10(6) compared with 0-93, 0-90, 3-10 and 2-49 times 10(6) for chloroquine, lucanthone, daunorubicin and doxorubicin respectively.
已制备了一系列氨基烷基氨基蒽醌作为潜在的嵌入剂。通过分光光度滴定法对这些化合物以及已知的嵌入药物氯喹、卢卡酮、柔红霉素和阿霉素与DNA的结合进行了表征。根据Scatchard图确定了每种化合物与DNA相互作用的缔合常数。合成的化合物的缔合常数在0 - 5至4 - 2×10⁶之间，而氯喹、卢卡酮、柔红霉素和阿霉素的缔合常数分别为0 - 93、0 - 90、3 - 10和2 - 49×10⁶。
