Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Osaka, Japan.
Taiwan J Obstet Gynecol. 2013 Jun;52(2):165-70. doi: 10.1016/j.tjog.2013.04.004.
In daily obstetric practice, oxytocin is one of the most frequently used drugs to stimulate uterine contraction. However, uterine sensitivity to oxytocin is profoundly different among pregnant women, which may reflect oxytocin receptor (OTR) expression in the uterus. We review here the literature focusing on OTR regulation in the human uterus. Recent progress in molecular biology has augmented our knowledge about OTR regulation in the uterus at the transcription level, although the totality of preparation for labor through OTR expression is still obscure.
在日常产科实践中，催产素是最常使用的药物之一，用于刺激子宫收缩。然而，孕妇对催产素的敏感性存在显著差异，这可能反映了子宫中催产素受体（OTR）的表达。我们在此综述了聚焦于人类子宫中 OTR 调节的文献。分子生物学的最新进展增加了我们对子宫中 OTR 转录水平调节的认识，但通过 OTR 表达来准备分娩的全部过程仍然不清楚。
