Li K C, Zernicke R F, Barnard R J, Li A F
Department of Physiological Science, UCLA, Los Angeles, USA.
Clin Biomech (Bristol). 1993 May;8(3):163-5. doi: 10.1016/0268-0033(93)90058-P.
A high-fat-sucrose diet can adversely affect calcium absorption, and thus bone-ligament junction strength may be compromised. To test this premise we examined the influence of a high-fat-sucrose diet on the femur-medial collateral ligament-tibia complex of rats. The mechanics and geometry of this bone-ligament-bone complex were measured, and the histomorphometry of the distal bone-ligament junction (tibial-medial collateral ligament) was examined. After 10 weeks the high-fat-sucrose and control (low-fat, complex-carbohydrate) diet groups showed no difference in medial collateral ligament cross-sectional area, but the mechanical integrity of high-fat-sucrose bone-ligament-bone complex was significantly less than the controls; for example, the maximum and failure loads were significantly less (30%) with the high-fat-sucrose diet. Cell density was also significantly less in the medial collateral ligaments of those rats on the high-fat-sucrose diet. Diets with relatively high proportions of fat and sucrose are not uncommon in North American and European nations, but little is known about the effects that these diets may have on growing bone and fibrous connective tissues. The results from the current study provide both a caution and a stimulus. The caution arises from the pronounced and adverse effects that a diet rich in fat and sucrose can have on the mechanical properties and structure of bone-ligament junctions in growing animals. The stimulus provided by these results is to examine the long-term consequences of such a diet on bone-ligament integrity and to assess the implications of a high-fat-sucrose diet for humans.
高脂高糖饮食会对钙的吸收产生不利影响，进而可能损害骨韧带连接强度。为验证这一假设，我们研究了高脂高糖饮食对大鼠股骨-内侧副韧带-胫骨复合体的影响。测量了该骨-韧带-骨复合体的力学性能和几何形状，并检查了远端骨韧带连接（胫骨-内侧副韧带）的组织形态计量学。10周后，高脂高糖饮食组和对照组（低脂、复合碳水化合物饮食）的内侧副韧带横截面积没有差异，但高脂高糖骨-韧带-骨复合体的力学完整性明显低于对照组；例如，高脂高糖饮食组的最大负荷和破坏负荷显著降低（30%）。高脂高糖饮食组大鼠内侧副韧带的细胞密度也显著降低。在北美和欧洲国家，脂肪和蔗糖比例相对较高的饮食并不少见，但人们对这些饮食可能对生长中的骨骼和纤维结缔组织产生的影响知之甚少。本研究结果既敲响了警钟，也带来了启发。警钟源于富含脂肪和蔗糖的饮食对生长中动物骨韧带连接的力学性能和结构可能产生的显著不利影响。这些结果带来的启发是，要研究这种饮食对骨韧带完整性的长期影响，并评估高脂高糖饮食对人类的影响。
