Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, United States.
Curr Opin Microbiol. 2013 Oct;16(5):531-7. doi: 10.1016/j.mib.2013.06.014. Epub 2013 Jul 31.
The relentless spread of antibiotic-resistant pathogens makes it imperative to develop new chemotherapeutic strategies to overcome infection. The bacterial cell wall has served as a rich source for both validated and unexploited pathways that are essential for virulence and survival. Lipoteichoic acids (LTAs) and wall teichoic acids (WTAs) are cell wall polymers that play fundamental roles in Gram-positive bacterial physiology and pathogenesis, and both have been proposed as novel antibacterial targets. Here we describe recent progress toward the discovery of teichoic acid biosynthesis inhibitors and their potential as antibiotics to combat Staphylococcus aureus infections.
抗生素耐药性病原体的无情传播使得开发新的化疗策略来克服感染变得至关重要。细菌细胞壁是验证和未开发的途径的丰富来源，这些途径对于毒力和生存至关重要。脂磷壁酸 (LTAs) 和壁磷壁酸 (WTAs) 是细胞壁聚合物，在革兰氏阳性细菌生理学和发病机制中发挥着基本作用，两者都被提议作为新的抗菌靶标。在这里，我们描述了在发现磷壁酸生物合成抑制剂及其作为抗生素对抗金黄色葡萄球菌感染方面的最新进展。
