磷脂酶C途径对瞬时受体电位通道的调控
Regulation of transient receptor potential channels by the phospholipase C pathway.
作者信息
Rohacs Tibor
机构信息
Rutgers, New Jersey Medical School, Newark, NJ, USA.
出版信息
Adv Biol Regul. 2013 Sep;53(3):341-55. doi: 10.1016/j.jbior.2013.07.004. Epub 2013 Jul 17.
Abstract
Transient Receptor Potential (TRP) channels were discovered while analyzing visual mutants in Drosophila. The protein encoded by the transient receptor potential (trp) gene is a Ca(2+) permeable cation channel activated downstream of the phospholipase C (PLC) pathway. While searching for homologs in other organisms, a surprisingly large number of mammalian TRP channels was cloned. The regulation of TRP channels is quite diverse, but many of them are either activated downstream of PLC, or modulated by it. This review will summarize the current knowledge on regulation of TRP channels by PLC, with special focus on TRPC-s, which can be considered as effectors of PLC and the heat- and capsaicin-sensitive TRPV1, which is modulated by the PLC pathway in a complex manner.
摘要
瞬时受体电位（TRP）通道是在分析果蝇视觉突变体时发现的。瞬时受体电位（trp）基因编码的蛋白质是一种Ca(2+) 通透性阳离子通道，在磷脂酶C（PLC）途径下游被激活。在寻找其他生物中的同源物时，克隆出了数量惊人的大量哺乳动物TRP通道。TRP通道的调节方式非常多样，但其中许多通道要么在PLC下游被激活，要么受到其调节。本综述将总结目前关于PLC对TRP通道调节的知识，特别关注可被视为PLC效应器的TRPC家族，以及以复杂方式受PLC途径调节的热和辣椒素敏感的TRPV1。
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