Pathophysiology of Neuronal Plasticity, Neurocentre Magendie, Inserm U862, University of Bordeaux, 146 rue Léo Saignat, Bordeaux F33077, France.
Neuropharmacology. 2014 Jan;76 Pt B:437-49. doi: 10.1016/j.neuropharm.2013.07.014. Epub 2013 Aug 2.
Transition to addiction is the shift from controlled to uncontrolled drug use that occurs after prolonged drug intake in a limited number of drug users. A major challenge of addiction research in recent years has been to develop models for studying this pathological transition. Toward this goal, a DSM-IV/5-based multi-symptomatic model of cocaine addiction has been developed in the rat. It is based on an operational translation of the main features of the disease. 1. Addiction is not just taking drug; it is a non-adaptive drug use: The procedure models addiction in relation to its clinical definition. 2. All drug users do not face the same individual risk of developing addiction: The model includes an individual-based approach. 3. Addiction develops after protracted periods of controlled drug use: This procedure allows for the study of the long-term shift from controlled drug use to addiction. We describe this model in detail and show how it can contribute to our understanding of the pathophysiology of cocaine addiction. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'.
成瘾转变是指在少数药物使用者长期摄入药物后，从受控药物使用转变为不受控药物使用的过程。近年来，成瘾研究的一个主要挑战是开发用于研究这种病理性转变的模型。为此，人们在大鼠中建立了基于 DSM-IV/5 的可卡因成瘾多症状模型。它基于对疾病主要特征的操作性转化。1. 成瘾不仅仅是吸毒，而是一种非适应性的药物使用：该程序将成瘾与临床定义联系起来进行建模。2. 并非所有药物使用者都面临着同样的个体成瘾风险：该模型包括基于个体的方法。3. 成瘾是在长期受控药物使用后发展起来的：该程序允许研究从受控药物使用到成瘾的长期转变。我们详细描述了这个模型，并展示了它如何有助于我们理解可卡因成瘾的病理生理学。本文是“NIDA 40 周年特刊”的一部分。
