钯催化的与苯硼酸的交叉偶联反应合成来源于胆酸的 24-苯基-24-氧代甾体。NMR 谱的特征和 X 射线结构。
Synthesis of 24-phenyl-24-oxo steroids derived from bile acids by palladium-catalyzed cross coupling with phenylboronic acid. NMR characterization and X-ray structures.
机构信息
Facultad de Química, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510 México, DF, México.
出版信息
Steroids. 2013 Nov;78(11):1092-7. doi: 10.1016/j.steroids.2013.07.008. Epub 2013 Aug 2.
Abstract
Palladium-catalyzed cross coupling of phenyboronic acid with acetylated bile acids in which the carboxyl functions have been activated by formation of a mixed anhydride with pivalic anhydride afforded moderate to good yield of 24-phenyl-24-oxo-steroids. Unambiguous assignments of the NMR signals were made with the aid of combined 1D and 2D NMR techniques. X-ray diffraction studies confirmed the obtained structures.
摘要
钯催化的苯硼酸与乙酰化胆酸的交叉偶联反应中，羧酸官能团通过与特戊酸酐形成混合酸酐而被激活，从而得到中等至良好收率的 24-苯基-24-氧代甾体。借助于一维和二维 NMR 技术的组合，对 NMR 信号进行了明确的归属。X 射线衍射研究证实了所得到的结构。
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