Laboratory of Molecular Oncology, Massachusetts General Hospital Cancer Center, Building 149, 13th Street, Charlestown, MA 02129, USA.
Curr Opin Cell Biol. 2013 Dec;25(6):735-40. doi: 10.1016/j.ceb.2013.07.012. Epub 2013 Aug 3.
The pRB tumor suppressor is traditionally seen as an important regulator of the cell cycle. pRB represses the transcriptional activation of a diverse set of genes by the E2F transcription factors and prevents inappropriate S-phase entry. Advances in our understanding of pRB have documented roles that extend beyond the cell cycle and this review summarizes recent studies that link pRB to the control of cell metabolism. pRB has been shown to regulate glucose tolerance, mitogenesis, glutathione synthesis, and the expression of genes involved in central carbon metabolism. Several studies have demonstrated that pRB directly targets a set of genes that are crucial for nucleotide metabolism, and this seems likely to represent one of the ways by which pRB influences the G1/S-phase transition and S-phase progression.
pRB 肿瘤抑制因子传统上被视为细胞周期的重要调节因子。pRB 通过 E2F 转录因子抑制多种基因的转录激活，并防止不适当的 S 期进入。我们对 pRB 的理解的进展证明了其作用超出了细胞周期的范围，本综述总结了最近将 pRB 与细胞代谢控制联系起来的研究。pRB 已被证明可调节葡萄糖耐量、有丝分裂、谷胱甘肽合成以及参与中心碳代谢的基因的表达。几项研究表明，pRB 直接靶向一组对核苷酸代谢至关重要的基因，这似乎是 pRB 影响 G1/S 期转换和 S 期进程的方式之一。
