Dupuytren University Hospital, Limoges, France.
Ann Thorac Surg. 2013 Sep;96(3):851-6. doi: 10.1016/j.athoracsur.2013.04.066. Epub 2013 Aug 2.
The management of acute type A aortic dissection (aTAAD) in octogenarian patients is controversial. This study analyzed the surgical outcomes to identify patients who should undergo operations.
Beginning in January 2000, we established a registry including all octogenarian patients operated on for type A acute aortic dissection. We evaluated 79 consecutive patients enrolled up to December 2010. Their median age was 81.6 years (range, 80 to 89 years). Sixteen patients (20%) presented a complicated type because of a neurologic deficit, mesenteric ischemia, a requirement for cardiopulmonary resuscitation, or some combination of those features. Operations followed the standard procedure recommended for younger patients. Follow-up was 95% complete (mean, 4.6±2.8 years).
The overall in-hospital mortality was 44.3%. The in-hospital mortality among patients with uncomplicated aTAAD was 33.3%. Multivariate analysis identified complicated aTAAD as the only risk factors for in-hospital mortality (p<0.0001). Postoperative complications occurred in 50 patients (68.5%) and were associated with a higher mortality (p<0.0001). The overall survival was 53% at 1 year and 32% at 5 years. In uncomplicated aTAAD, the overall survival was 63% at 1 year and 38% at 5 years.
Octogenarians with uncomplicated aTAAD benefit from emergency surgical repair. In those patients, early and midterm outcomes are good and are similar to those in published series of younger patients. Complicated aTAAD should be medically managed.
80 岁以上急性 A 型主动脉夹层(aTAAD)患者的治疗方法存在争议。本研究旨在分析手术结果,以明确哪些患者应接受手术治疗。
自 2000 年 1 月起,我们建立了一个包含所有接受 A 型急性主动脉夹层手术的 80 岁以上患者的注册库。我们评估了截至 2010 年 12 月登记的 79 例连续患者。患者的中位年龄为 81.6 岁(范围为 80 至 89 岁)。16 例(20%)患者因神经功能障碍、肠系膜缺血、心肺复苏需要或这些特征的某种组合而表现为复杂型。手术方法遵循推荐给年轻患者的标准程序。随访率为 95%(平均随访时间为 4.6±2.8 年)。
总的院内死亡率为 44.3%。单纯型 aTAAD 的院内死亡率为 33.3%。多因素分析显示,复杂型 aTAAD 是院内死亡的唯一危险因素(p<0.0001)。50 例(68.5%)患者术后发生并发症,且与死亡率增加相关(p<0.0001)。总的 1 年生存率为 53%,5 年生存率为 32%。单纯型 aTAAD 的 1 年生存率为 63%,5 年生存率为 38%。
单纯型 aTAAD 的 80 岁以上患者可从急诊手术修复中获益。这些患者的早期和中期结果良好,与年轻患者发表的系列结果相似。复杂型 aTAAD 应采用内科治疗。