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双侧肺动脉环缩术作为高危新生儿的抢救干预措施。

Bilateral pulmonary artery banding as rescue intervention in high-risk neonates.

机构信息

Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin and Herma Heart Center at Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53201, USA.

出版信息

Ann Thorac Surg. 2013 Sep;96(3):885-90. doi: 10.1016/j.athoracsur.2013.05.049. Epub 2013 Aug 2.

Abstract

BACKGROUND

Presentation in shock and preoperative infection remain risk factors for neonatal cardiac surgery. This report describes bilateral pulmonary artery banding (bPAB) in ductal-dependent lesions with systemic outflow obstruction as rescue intervention before surgery with cardiopulmonary bypass in these high-risk neonates.

METHODS

A retrospective chart review was conducted for 10 patients who underwent bPAB before conventional surgery with cardiopulmonary bypass. Patient characteristics including birth weight, gestational age, cardiac and noncardiac diagnoses, preoperative and postoperative markers of organ function, and outcome measures were examined.

RESULTS

The majority of patients (8 of 10) were considered high-risk owing to multiorgan dysfunction syndrome. The median age at bPAB was 12 days (range, 5 to 26 days), and the median interval between bPAB and second surgery was 10.5 days (range, 5 to 79 days). Organ function improved after admission and continued to improve after bPAB in 9 of 10 patients. No patient experienced new complications between bPAB and subsequent operation. Of 8 patients who had stage I palliation, 5 have undergone or are awaiting completion Fontan, 1 underwent Kawashima procedure, 1 underwent orthotopic heart transplant, and 1 with hypoplastic left heart syndrome and intact atrial septum died at 44 days old. Both patients who underwent biventricular repair are alive and well. Median follow-up for survivors was 2.9 years (range, 0.25 to 6.25 years).

CONCLUSIONS

Bilateral pulmonary artery banding is safe in ductal-dependent lesions with systemic outflow obstruction. High-risk patients with preoperative organ dysfunction or infection can recover within a short period and become lower risk candidates for complex congenital heart surgery using cardiopulmonary bypass.

摘要

背景

在依赖于体循环的心脏畸形中,休克和术前感染仍然是心脏手术的危险因素。本研究报告描述了在体外循环下进行常规心脏手术之前,对于存在体肺分流依赖性病变和流出道梗阻的高危新生儿,采用双侧肺动脉环缩术(bPAB)作为一种抢救干预措施。

方法

回顾性分析了 10 例行 bPAB 的患儿的病历资料,这些患儿均存在依赖于体循环的病变和流出道梗阻,在接受体外循环下常规心脏手术之前先行 bPAB。研究了患儿的一般特征(包括出生体重、胎龄、心脏和非心脏诊断、术前和术后器官功能标志物)以及预后评估指标。

结果

大多数患儿(10 例中的 8 例)由于多器官功能障碍综合征而被认为是高危患儿。bPAB 的中位年龄为 12 天(范围,5 至 26 天),bPAB 与第二次手术之间的中位间隔为 10.5 天(范围,5 至 79 天)。10 例患儿中,有 9 例在入院后和 bPAB 后器官功能均有改善。在 bPAB 与后续手术之间,没有患儿出现新的并发症。8 例行一期姑息手术的患儿中,5 例行 Fontan 手术,1 例行 Kawashima 手术,1 例行原位心脏移植,1 例存在左心发育不良和完整的房间隔,该患儿于 44 天死亡,1 例存在左心发育不良和完整的房间隔的患儿在等待完成 Fontan 手术。行双心室修复术的 2 例患儿均存活且状况良好。存活患儿的中位随访时间为 2.9 年(范围,0.25 至 6.25 年)。

结论

在存在体肺分流依赖性病变和流出道梗阻的情况下,行双侧肺动脉环缩术是安全的。对于术前存在器官功能障碍或感染的高危患儿,在短期内可恢复并降低体外循环下复杂先天性心脏手术的风险。

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