Yamasaki Takato, Umezu Kentaro, Toba Shuhei, Ishikawa Renta, Bessho Saki, Ito Hisato, Shomura Yu, Ohashi Hiroyuki, Sawada Hirofumi, Mitani Yoshihide, Shimpo Hideto, Takao Motoshi
Department of Thoracic and Cardiovascular Surgery, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Department of Pediatrics, Mie University Graduate School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Heart Vessels. 2024 Oct;39(10):891-898. doi: 10.1007/s00380-024-02412-7. Epub 2024 May 11.
Various surgical approaches address complex heart disease with arch anomalies. Bilateral pulmonary artery banding (bPAB) is a strategy for critically ill patients with complex arch anomalies. Some reports argued the potential effect of bPAB on the growth of the left ventricular outflow tract (LVOT) during inter-stage after bPAB. This study aimed to analyze the LVOT growth for biventricular repair candidates with arch anomaly and systemic ventricular outflow tract (SVOT) for univentricular repair candidates with arch anomaly. This retrospective study analyzed 17 patients undergoing initial bPAB followed by arch repair. The Z-scores of LVOT and SVOT were compared between pre-bPAB and pre-arch repair. Patient characteristics, transthoracic echocardiogram data, and PAB circumferences were reviewed. The diameter of the minimum LVOT for biventricular repair (BVR) candidates, the pulmonary valve (neo-aortic valve, neo-AoV) and the pulmonary trunk (the neo-ascending aorta, neo-AAo) for univentricular repair (UVR) candidates, and the degree of aortic or neo-aortic insufficiency in each candidate was statistically analyzed. 17 patients were divided into the UVR candidates (group U) with 9 patients and the BVR candidates (group B) with 8 patients. In group B, the median value of the Z-score of the minimum LVOT increased from -3.2 (range: - 4.1 ~ - 1.0) at pre-PAB to -2.8 (range: - 3.6 ~ - 0.3) at pre-arch repair with a significant difference (p = 0.012). In group U, the median value of the Z-score of the neo-AoV increased from 0.5 (range: - 1.0 ~ 1.7) at pre-bPAB to 1.2 (range: 0.2 ~ 1.9) at pre-arch repair with a significant difference (p < 0.01). The median value of the Z-score of the neo-AAo was also increased from 3.1 (range: 1.5 ~ 4.6) to 4.3 (range: 3.1 ~ 5.9) with a significant difference (p = 0.028). The growth of the LVOT for BVR candidates and SVOT for UVR candidates during the inter-stage between bPAB and arch repair was observed. These results suggest the potential advantage of bPAB in surgical strategies. Further research is needed to validate these findings and refine surgical approaches.
多种手术方法可用于治疗合并主动脉弓畸形的复杂心脏病。双侧肺动脉环缩术(bPAB)是针对患有复杂主动脉弓畸形的危重症患者的一种治疗策略。一些报告认为bPAB对bPAB术后过渡期左心室流出道(LVOT)的生长有潜在影响。本研究旨在分析合并主动脉弓畸形的双心室修复候选者的LVOT生长情况,以及合并主动脉弓畸形的单心室修复候选者的体心室流出道(SVOT)情况。这项回顾性研究分析了17例接受初次bPAB继而进行主动脉弓修复的患者。比较了bPAB术前和主动脉弓修复术前LVOT和SVOT的Z值。回顾了患者特征、经胸超声心动图数据和PAB周长。对双心室修复(BVR)候选者的最小LVOT直径、单心室修复(UVR)候选者的肺动脉瓣(新主动脉瓣,neo-AoV)和肺动脉干(新升主动脉,neo-AAo),以及每个候选者的主动脉或新主动脉瓣关闭不全程度进行了统计分析。17例患者分为9例的UVR候选者(U组)和8例的BVR候选者(B组)。在B组中,最小LVOT的Z值中位数从PAB术前的-3.2(范围:-4.1-1.0)增加到主动脉弓修复术前的-2.8(范围:-3.6-0.3),差异有统计学意义(p=0.012)。在U组中,neo-AoV的Z值中位数从bPAB术前的0.5(范围:-1.01.7)增加到主动脉弓修复术前的1.2(范围:0.21.9),差异有统计学意义(p<0.01)。neo-AAo的Z值中位数也从3.1(范围:1.54.6)增加到4.3(范围:3.15.9),差异有统计学意义(p=0.028)。观察到BVR候选者的LVOT和UVR候选者的SVOT在bPAB和主动脉弓修复的过渡期内有所生长。这些结果提示了bPAB在手术策略中的潜在优势。需要进一步的研究来验证这些发现并完善手术方法。