耐利奈唑胺和突变表型的金黄色葡萄球菌分离株在成人囊性纤维化患者中的快速出现。
Rapid emergence of resistance to linezolid and mutator phenotypes in Staphylococcus aureus isolates from an adult cystic fibrosis patient.
机构信息
Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France.
出版信息
Antimicrob Agents Chemother. 2013 Oct;57(10):5186-8. doi: 10.1128/AAC.01392-13. Epub 2013 Aug 5.
Abstract
Linezolid has emerged as an important therapeutic option for the treatment of Staphylococcus aureus in patients with cystic fibrosis. We report the rapid emergence, upon treatment with linezolid, of linezolid-resistant S. aureus clinical isolates through the accumulation of resistance-associated 23S rRNA mutations, together with acquisition of an altered mutator phenotype.
摘要
利奈唑胺已成为治疗囊性纤维化患者金黄色葡萄球菌感染的重要治疗选择。我们报道了在利奈唑胺治疗过程中，由于耐药相关 23S rRNA 突变的积累，以及获得改变的突变体表型，导致利奈唑胺耐药的金黄色葡萄球菌临床分离株的迅速出现。
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本文引用的文献
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Resistance to linezolid in a methicillin-susceptible Staphylococcus aureus clinical isolate without previous exposure to oxazolidinones.耐万古霉素金黄色葡萄球菌临床分离株对利奈唑胺的耐药性，该分离株之前未接触过恶唑烷酮类药物。
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