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本文引用的文献

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MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.MRE11 有助于从基因组 DNA 中去除人拓扑异构酶 II 复合物。
Biol Open. 2012 Sep 15;1(9):863-73. doi: 10.1242/bio.20121834. Epub 2012 Jul 11.
2
Isolation and quantitation of topoisomerase complexes accumulated on Escherichia coli chromosomal DNA.在大肠杆菌染色体 DNA 上积累的拓扑异构酶复合物的分离和定量。
Antimicrob Agents Chemother. 2012 Nov;56(11):5458-64. doi: 10.1128/AAC.01182-12. Epub 2012 Aug 6.
3
DNA repair factor MRE11/RAD50 cleaves 3'-phosphotyrosyl bonds and resects DNA to repair damage caused by topoisomerase 1 poisons.DNA 修复因子 MRE11/RAD50 可切割 3'-磷酸酪氨酸键，并切除 DNA，以修复拓扑异构酶 1 抑制剂所造成的损伤。
J Biol Chem. 2011 Dec 30;286(52):44945-51. doi: 10.1074/jbc.M111.299347. Epub 2011 Oct 28.
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Effects of DNA and protein size on substrate cleavage by human tyrosyl-DNA phosphodiesterase 1.人类酪氨酰 DNA 磷酸二酯酶 1 对底物切割的 DNA 和蛋白质大小的影响。
Biochem J. 2011 Jun 15;436(3):559-66. doi: 10.1042/BJ20101841.
5
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.聚（ADP-核糖）聚合酶和 XPF-ERCC1 参与修复哺乳动物细胞中拓扑异构酶 I 诱导的 DNA 损伤的不同途径。
Nucleic Acids Res. 2011 May;39(9):3607-20. doi: 10.1093/nar/gkq1304. Epub 2011 Jan 11.
6
The SMC-like protein complex SbcCD enhances DNA polymerase IV-dependent spontaneous mutation in Escherichia coli.SbcCD 样 SMC 蛋白复合体增强大肠杆菌中依赖于 DNA 聚合酶 IV 的自发突变。
J Bacteriol. 2011 Feb;193(3):660-9. doi: 10.1128/JB.01166-10. Epub 2010 Dec 3.
7
A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.一种修复拓扑异构酶介导的DNA损伤的人类5'-酪氨酰DNA磷酸二酯酶。
Nature. 2009 Oct 1;461(7264):674-8. doi: 10.1038/nature08444.
8
World Health Organization ranking of antimicrobials according to their importance in human medicine: A critical step for developing risk management strategies for the use of antimicrobials in food production animals.世界卫生组织根据抗菌药物在人类医学中的重要性进行的排名：制定食品生产动物抗菌药物使用风险管理策略的关键一步。
Clin Infect Dis. 2009 Jul 1;49(1):132-41. doi: 10.1086/599374.
9
Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA.从DNA上去除共价结合的拓扑异构酶I和II时，Rad32（Mre11）核酸酶和Ctp1（CtIP）的不同要求。
Mol Cell. 2009 Jan 16;33(1):117-23. doi: 10.1016/j.molcel.2008.11.021.
10
Effect of anaerobic growth on quinolone lethality with Escherichia coli.厌氧生长对大肠杆菌喹诺酮致死率的影响。
Antimicrob Agents Chemother. 2007 Jan;51(1):28-34. doi: 10.1128/AAC.00739-06. Epub 2006 Oct 16.

SbcCD 介导的大肠埃希菌共价拓扑异构酶-DNA 复合物的加工。

SbcCD-mediated processing of covalent gyrase-DNA complex in Escherichia coli.

机构信息

Department of Biochemistry & Molecular Biology, New York Medical College, Valhalla, New York, USA.

出版信息

Antimicrob Agents Chemother. 2013 Oct;57(10):5116-9. doi: 10.1128/AAC.00130-13. Epub 2013 Aug 5.

DOI:10.1128/AAC.00130-13
PMID:23917316
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3811449/
Abstract

Quinolones trap the covalent gyrase-DNA complex in Escherichia coli, leading to cell death. Processing activities for trapped covalent complex have not been characterized. A mutant strain lacking SbcCD nuclease activity was examined for both accumulation of gyrase-DNA complex and viability after quinolone treatment. Higher complex levels were found in ΔsbcCD cells than in wild-type cells after incubation with nalidixic acid and ciprofloxacin. However, SbcCD activity protected cells against the bactericidal action of nalidixic acid but not ciprofloxacin.

摘要

喹诺酮类药物会捕获大肠埃希菌中的共价拓扑异构酶-DNA 复合物，从而导致细胞死亡。目前尚未对被捕获的共价复合物的加工活性进行表征。我们研究了缺乏 SbcCD 核酸内切酶活性的突变菌株在喹诺酮类药物处理后的共价拓扑异构酶-DNA 复合物积累和存活情况。与野生型细胞相比，在用萘啶酸和环丙沙星孵育后，Δ sbcCD 细胞中的复合物水平更高。然而，SbcCD 活性可保护细胞免受萘啶酸的杀菌作用，但不能保护细胞免受环丙沙星的杀菌作用。