Okada T, Furukawa S
Department of Pediatrics, Kagawa Children Hospital, National Sanatorium.
Jpn J Antibiot. 1990 May;43(5):895-900.
We have evaluated the effectiveness and safety of norfloxacin (NFLX) in 18 children with infectious diseases. Doses ranging from 5.6 to 18.8 mg/kg/day for t.i.d. or q.i.d. were used. The causative bacteria were Campylobacter jejuni in 3 cases, Salmonella typhimurium in 1, Staphylococcus aureus in 2, Haemophilus influenzae in 1 and unknown in 11 cases. Except 1 strain of S. aureus, all the bacteria mentioned above were eradicated. Clinical effects were excellent in 8, good in 8, poor in 2, and the total efficacy rate was 88.9%. No side effects nor abnormal laboratory test results were observed. These results have shown that the NFLX is a usefull drug for infectious diseases in the pediatric field.
我们评估了诺氟沙星（NFLX）对18例患有传染病儿童的有效性和安全性。采用每日剂量为5.6至18.8mg/kg、每日三次或四次给药。病原菌为空肠弯曲菌3例、鼠伤寒沙门菌1例、金黄色葡萄球菌2例、流感嗜血杆菌1例，11例病原菌不明。除1株金黄色葡萄球菌外，上述所有细菌均被根除。临床疗效优8例，良8例，差2例，总有效率为88.9%。未观察到副作用及实验室检查结果异常。这些结果表明，诺氟沙星是儿科领域治疗传染病的有效药物。
