Kuno K, Ogawa A, Nakao Y, Hayakawa F, Ando Y, Kito O
Department of Pediatrics, Anjo Kosei Hospital.
Jpn J Antibiot. 1990 May;43(5):842-51.
Bacteriological and clinical studies on norfloxacin (NFLX) were carried out in the field of pediatrics, and the results obtained are summarized as follows: 1. The MICs of NFLX against clinically isolated organisms were determined to compare with MICs of nalidixic acid, amoxicillin, cefaclor, erythromycin and fosfomycin. NFLX had low MICs against both Gram-positive and Gram-negative bacteria and, particularly, showed higher antimicrobial activity to Escherichia coli, Salmonella sp., Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae and Campylobacter jejuni than any other drugs tested. 2. Seventeen pediatric patients (11 cases of enteritis, 4 cases of urinary tract infections, 1 case of tonsillitis and 1 case of pyoderma) were treated orally with NFLX in daily doses ranging from 3.1 to 16.7 mg/kg t.i.d. for 6-14 days. Rates of clinical effectiveness and bacterial elimination were 94.1% and 58.8%, respectively. 3. None of the treated children showed clinical symptoms indicating the occurrence of side effects nor abnormal laboratory findings except 1 patient with eosinophilia. These results indicate the usefulness of NFLX in the treatment of bacterial infections in the pediatric field.
在儿科领域开展了关于诺氟沙星（NFLX）的细菌学和临床研究，所得结果总结如下：1. 测定了NFLX对临床分离菌株的最低抑菌浓度（MIC），并与萘啶酸、阿莫西林、头孢克洛、红霉素和磷霉素的MIC进行比较。NFLX对革兰氏阳性菌和革兰氏阴性菌的MIC均较低，特别是对大肠杆菌、沙门氏菌属、肺炎克雷伯菌、铜绿假单胞菌、流感嗜血杆菌和空肠弯曲菌的抗菌活性高于所测试的其他任何药物。2. 对17例儿科患者（11例肠炎、4例尿路感染、1例扁桃体炎和1例脓疱病）口服NFLX进行治疗，每日剂量为3.1至16.7mg/kg，一日三次，疗程6至14天。临床有效率和细菌清除率分别为94.1%和58.8%。3. 除1例嗜酸性粒细胞增多患者外，接受治疗的儿童均未出现表明有副作用发生的临床症状，实验室检查结果也均未出现异常。这些结果表明NFLX在儿科领域治疗细菌感染方面具有实用性。
