甲型H5N1、H1N1和H7N9禽流感在人间暴发期间药品储备、疫苗研发及相关政策的变化与不足。

Changes in and shortcomings of drug stockpiling, vaccine development and related policies during outbreaks of avian influenza A H5N1, H1N1, and H7N9 among humans.

作者信息

Mei L, Tang Q, Cui Y M, Tobe R G, Selotlegeng L, Ali A H, Xu L Z

机构信息

Department of Health Care Management and Maternal and Child Health, Shandong University, Ji'nan, Shandong, China.

出版信息

Drug Discov Ther. 2013 Jun;7(3):95-100.

PMID:23917856

Abstract

The purpose of this paper is to provide a reference for the future stockpiling of drugs and developing vaccines for treatment of emerging infectious diseases by summarizing the status of drug stockpiling, vaccine development, and related policies during three major outbreaks of avian influenza among humans (H5N1 in 2003, H1N1 in 2009, and H7N9 in 2013). Documents regarding drug stockpiling and vaccine development during three influenza outbreaks have been reviewed. Results indicated that the response to pandemic influenza outbreaks has improved markedly in terms of stockpiles of antivirals and vaccine development. These improvements also suggest advances in related policy planning. These trends also foreshadow better prospects for prevention and control of emerging infectious diseases. However, the rationality of drug stockpiling and international cooperation still needs to be enhanced.

摘要

本文旨在通过总结人感染禽流感三次重大疫情（2003年H5N1、2009年H1N1和2013年H7N9）期间的药品储备、疫苗研发及相关政策状况，为未来新兴传染病治疗药物储备和疫苗研发提供参考。回顾了三次流感疫情期间有关药品储备和疫苗研发的文件。结果表明，在抗病毒药物储备和疫苗研发方面，对大流行性流感疫情的应对有了显著改善。这些改进也表明相关政策规划取得了进展。这些趋势也预示着新兴传染病防控的前景更加美好。然而，药品储备的合理性和国际合作仍需加强。