Yan Xiu-feng, Ni Qing, Wei Jun-ping, Lin Lan
Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Chin J Integr Med. 2014 Aug;20(8):633-40. doi: 10.1007/s11655-013-1462-2. Epub 2013 Aug 5.
To evaluate the efficacy and safety of "Three-Typed Syndrome Differentiation" (TTSD) in treating type 2 diabetes mellitus patients.
A systematic review and meta-analysis was done based on the clinical diabetes treatment literature of the "TTSD". Overseas databases like the PubMed/MEDLINE, EMBASE, Cochrane Library and Cochrane Central Register of Controlled Clinical Trials, and China databases like China Biology Medicine Disc (CBM), Chinese national Knowledge Infrastructure (CNKI), Wanfang database, and VIP database, without limitation on language, were included with the time limitation from Jan 1982 to Dec 2012 by retrieval of relative original clinical research articles.
Nineteen articles where contains 1,840 diabetes patients were obtained, in which no adverse reactions were reported. Of these, 14 literatures involved the effect of fasting blood glucose (FBG), 10 involved that of postprandial 2-h blood glucose (P2hBG), and 19 involved the overall efficacy based on the national Chinese medicine (CM) diagnosis and treatment standard of diabetes. All the meta-analysis results prefer to the "TTSD" groups (CM+Western medicine Based on TTSD). The results show that, beside the efficacy of Western medicine, the concentrations of FBG and P2hBG in "TTSD" groups continue to drop with statistical significance. For "TTSD" groups, the FBG subsequently dropped 1.03 mmol/L, 95%CI [1.24,0.82] P <0.00001), the P2hBG subsequently dropped 1.09 mmol/L, 95% CI [1.61, 0.57] (P <0.0001), and the overall efficacies benefit 3.46 times those of Western medicine alone, 95% CI [2.67,4.48] (P <0.00001).
The CM by the diagnosis and treatment of type 2 diabetes based on TTSD might be safe and effective, and could better improve both blood glucose and the overall status of patients, including symptoms.
评价“三型辨证”治疗2型糖尿病患者的疗效及安全性。
基于“三型辨证”的临床糖尿病治疗文献进行系统评价和荟萃分析。纳入海外数据库如PubMed/MEDLINE、EMBASE、Cochrane图书馆和Cochrane临床对照试验中心注册库，以及中国数据库如中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方数据库和维普数据库，检索1982年1月至2012年12月期间的相关原始临床研究文章，不限语言。
共获得19篇文章，包含1840例糖尿病患者，均未报告不良反应。其中，14篇文献涉及空腹血糖（FBG）的影响，10篇涉及餐后2小时血糖（P2hBG）的影响，19篇根据中国中医糖尿病诊疗标准涉及总体疗效。所有荟萃分析结果均倾向于“三型辨证”组（基于三型辨证的中医+西医）。结果显示，除西药疗效外，“三型辨证”组的FBG和P2hBG浓度持续下降，具有统计学意义。对于“三型辨证”组，FBG随后下降1.03 mmol/L，95%CI[1.24,0.82]，P<0.00001），P2hBG随后下降1.09 mmol/L，95%CI[1.61,0.57]（P<0.0001），总体疗效比单纯西药高3.46倍,95%CI[2.67,4.48]（P<0.00001）。
基于三型辨证的2型糖尿病中医诊疗可能安全有效，能更好地改善患者血糖及包括症状在内的整体状况。
