Howell Carol A, Sandeman Susan R, Phillips Gary J, Mikhalovsky Sergey V, Tennison Stephen R, Rawlinson Anthony P, Kozynchenko Oleksandr P
Biomaterials and Medical Devices Research Group, School of Pharmacy & Biomolecular Sciences, University of Brighton, Brighton - United Kingdom.
Int J Artif Organs. 2013 Oct 3;36(9):624-32. doi: 10.5301/ijao.5000231. Epub 2013 Aug 2.
The aim of the present study was to develop and investigate nanoporous activated carbon materials for their ability to adsorb inflammatory cytokines directly from blood, for a range of therapeutic applications, including: systemic inflammatory response syndrome (SIRS) related to sepsis, cardio-pulmonary by-pass surgery, or ischemic reperfusion injury. Building on the previously established relationship between the porous structure of beaded polymer-derived activated carbon and its capacity to adsorb inflammatory molecules, we have developed and characterized monolithic porous carbon columns produced from the same polymer precursor matrix as carbon microbeads. The monolithic columns developed were assessed for their ability to adsorb inflammatory molecules from blood in a circulating system. Preliminary findings demonstrated good removal of the inflammatory cytokines IL-8 (100% removal), IL-6 (80% removal), and TNF (51% removal) from blood. The efficiency of cleansing is dependent on the size of the adsorbed molecule and the porous structure of the monolith, highlighting their potential for use as a hemoadsorption device.
本研究的目的是开发和研究纳米多孔活性炭材料，以考察其直接从血液中吸附炎性细胞因子的能力，用于一系列治疗应用，包括：与败血症、心肺旁路手术或缺血再灌注损伤相关的全身炎症反应综合征（SIRS）。基于先前建立的珠状聚合物衍生活性炭的多孔结构与其吸附炎性分子能力之间的关系，我们开发并表征了由与碳微珠相同的聚合物前体基质制成的整体多孔碳柱。对所开发的整体柱在循环系统中从血液中吸附炎性分子的能力进行了评估。初步研究结果表明，该材料能有效去除血液中的炎性细胞因子白细胞介素-8（IL-8，去除率100%）、白细胞介素-6（IL-6，去除率80%）和肿瘤坏死因子（TNF，去除率51%）。净化效率取决于被吸附分子的大小和整体柱的多孔结构，突出了其作为血液吸附装置的应用潜力。
