Department of Microbiology & Clinical Pathology, National AIDS Research Institute, Pune, India.
Trans R Soc Trop Med Hyg. 2013 Oct;107(10):648-52. doi: 10.1093/trstmh/trt067. Epub 2013 Aug 4.
Diarrhea in HIV infected individuals is a common complication seen in about 90% of patients in developing countries. The objective of this study was to identify enteric pathogens in HIV infected and HIV uninfected individuals in Pune.
This study was conducted from January 2009 to May 2010 on 331 consecutive patients presenting with diarrhea admitted at Naidu Municipal Corporation Hospital, Pune and processed using conventional methods.
Intestinal parasitic pathogens were detected in 60% (39/65) of HIV infected and 14.3 (38/266) of HIV uninfected individuals. Bacterial pathogens were detected in 34% (22/65) of HIV infected individuals and 28.2% (75/266) of the HIV uninfected individuals. The common enteric pathogens detected in HIV infected individuals were Cystoisospora belli (28%, 18/65) followed by Cryprotosporidium parvum (12%, 8/65). In HIV uninfected individuals Entamoeba histolytica (7.1%, 19/266) followed by Shigella flexnari (4.9%, 13/266) were the most common pathogens. The difference in detection of enteric parasites in HIV infected individuals and HIV uninfected individuals was found to be significant (p < 0.01).
Intestinal parasitic pathogens are more common in HIV infected antiretroviral therapy naïve patients. Early detection of enteric pathogens by routine examination of stool samples will help in the management and to improve the quality of life for HIV infected individuals.
在发展中国家，约 90%的 HIV 感染者会出现腹泻，这是一种常见并发症。本研究旨在确定浦那 HIV 感染者和未感染者中的肠道病原体。
本研究于 2009 年 1 月至 2010 年 5 月在浦那的 Naidu 市政公司医院对 331 例连续出现腹泻症状的患者进行了研究，使用常规方法进行处理。
在 60%（39/65）的 HIV 感染者和 14.3%（38/266）的未感染者中检测到肠道寄生虫病原体。在 34%（22/65）的 HIV 感染者和 28.2%（75/266）的未感染者中检测到细菌病原体。在 HIV 感染者中，常见的肠道病原体是隐孢子虫（28%，18/65），其次是微小隐孢子虫（12%，8/65）。在未感染者中，溶组织内阿米巴（7.1%，19/266），其次是福氏志贺菌（4.9%，13/266）是最常见的病原体。HIV 感染者和未感染者中肠道寄生虫的检出率差异有统计学意义（p < 0.01）。
肠道寄生虫病原体在未接受抗逆转录病毒治疗的 HIV 感染者中更为常见。通过常规粪便检查早期发现肠道病原体有助于管理并改善 HIV 感染者的生活质量。
