Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
J Med Virol. 2013 Jul;85(7):1163-9. doi: 10.1002/jmv.23561.
The geographic distribution, demographics, epidemiology, host factors, and clinical characteristics of persistent HCV-6 infection in China need further characterization. This multicenter study enrolled 63 patients with persistent HCV-6 infection and 63 patients with persistent HCV-1 infection as controls. Blood biochemistry, quantitation of HCV RNA levels, and identification of host IL-28B genotypes (rs12979860, rs8099917, and rs12980275) and ITPA genotype (rs1127354) were performed to estimate potential variability in host factors that may affect response to treatment. The mean HCV-6 RNA level (3.8E6 IU/ml) was significantly higher than that in patients infected with HCV-1 (1.7E6 IU/ml; P < 0.001). Patients persistently infected with HCV-6 had a high prevalence of IL-28B rs12979860 CC genotype (92.1%), rs8099917 TT genotype (93.7%), and rs12980275 AA genotype (90.5%). Their prevalence in patients infected with HCV-1 was only modestly lower (82.5%, 84.1%, and 82.5%, respectively; P > 0.05). The inosine triphosphate pyrophosphatase (ITPA) SNP rs1127354 CC genotype was present in 66.7% of patients infected with HCV-6, comparable to that of patients infected with HCV-1 (65.1%; P > 0.05). There were no differences in the liver function, proportion of hepatic cirrhosis patients or patients with increased serum glucose between these two groups. Persistent HCV-6 infection in Chinese Han is found mainly in the southern China. Chinese Han with chronic HCV-1 or HCV-6 infection have IL-28B genotypes, suggesting responsiveness to interferon-based pharmacotherapy. Most patients (67%) possess the ITPA genotype associated with susceptibility to ribavirin-induced hemolysis. The routes of transmission for HCV-6 genotype were more diversified than HCV-1 genotype. The outbreak of HCV-6 infection through blood transfusion progressed faster than HCV-1.
在中国，需要进一步描述持续性 HCV-6 感染的地理分布、人口统计学、流行病学、宿主因素和临床特征。这项多中心研究纳入了 63 例持续性 HCV-6 感染患者和 63 例持续性 HCV-1 感染患者作为对照。进行了血液生化学、HCV RNA 水平定量检测以及宿主 IL-28B 基因型（rs12979860、rs8099917 和 rs12980275）和 ITPA 基因型（rs1127354）鉴定，以评估可能影响治疗反应的宿主因素的潜在变异性。HCV-6 RNA 水平（3.8E6IU/ml）明显高于 HCV-1 感染患者（1.7E6IU/ml；P<0.001）。持续性 HCV-6 感染患者 IL-28B rs12979860 CC 基因型（92.1%）、rs8099917 TT 基因型（93.7%）和 rs12980275 AA 基因型（90.5%）的流行率较高。而 HCV-1 感染患者的流行率则略低（分别为 82.5%、84.1%和 82.5%；P>0.05）。肌苷三磷酸磷酸酶（ITPA）SNP rs1127354 CC 基因型在 66.7%的 HCV-6 感染患者中存在，与 HCV-1 感染患者相似（65.1%；P>0.05）。两组患者的肝功能、肝硬化患者比例或血清葡萄糖升高患者比例无差异。中国汉族人群中持续性 HCV-6 感染主要发生在中国南方。中国汉族慢性 HCV-1 或 HCV-6 感染者具有 IL-28B 基因型，提示对干扰素为基础的药物治疗有反应性。大多数患者（67%）具有易发生利巴韦林诱导溶血性的 ITPA 基因型。HCV-6 基因型的传播途径比 HCV-1 基因型更加多样化。HCV-6 感染通过输血传播的爆发速度快于 HCV-1。
