中国儿童丙型肝炎病毒感染与白细胞介素 28B 基因多态性的关系。
Association of Hepatitis C Virus Infection and Interleukin-28B Gene Polymorphism in Chinese Children.
机构信息
Rong-Rong Wu, Department of Pharmacy, Beijing 302 Hospital, Beijing China.
Feng-Qun Liu, Department of Pharmacy, Beijing 302 Hospital, Beijing China.
出版信息
Pak J Med Sci. 2014 May;30(3):519-24. doi: 10.12669/pjms.303.4267.
OBJECTIVE
To preliminarily explore the association of rs12979860 and rs8099917 SNPs with chronic HCV infection in Chinese Han children.
METHODS
Chronic HCV infection patients (n=277; 1-17 years old, 4.5 years old in average) and healthy subjects (n=150, children; 2-17 years old, 5.2 years old in average) were recruited and tested by PCR combining direct sequencing. The differences between the rs12979860 and rs8099917 genotypes in patients and healthy subjects were compared.
RESULTS
The genetic variations at rs12979860 and rs8099917 in chronic hepatitis C (CHC) children and healthy subjects did not differ significantly. The frequency of spontaneous clearance in CHC children was higher (47%), which is related to the genetic variations. The histological changes of patients were more significant compared to their clinical and biochemical indices, but they did not correlate with the genetic mutations at rs12979860 and rs8099917 significantly.
CONCLUSION
The rs12979860 and rs8099917 SNPs are independent factors predicting the spontaneous clearance of Chinese CHC children patients. The correlation between diseases outcomes are in need of further study.
目的
初步探讨 rs12979860 和 rs8099917 单核苷酸多态性与中国汉族儿童慢性 HCV 感染的关系。
方法
招募慢性 HCV 感染患者（n=277；1-17 岁，平均年龄 4.5 岁）和健康对照者（n=150，儿童；2-17 岁，平均年龄 5.2 岁），并通过 PCR 结合直接测序进行检测。比较患者和健康对照组 rs12979860 和 rs8099917 基因型的差异。
结果
慢性丙型肝炎（CHC）儿童和健康对照者 rs12979860 和 rs8099917 的遗传变异无显著差异。CHC 儿童的自发清除率较高（47%），这与遗传变异有关。与临床和生化指标相比，患者的组织学变化更为显著，但与 rs12979860 和 rs8099917 基因变异无显著相关性。
结论
rs12979860 和 rs8099917 SNP 是预测中国 CHC 儿童患者自发清除的独立因素。疾病结局之间的相关性需要进一步研究。
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