Emons G, Ghadimi M, Grade M
Allgemein-, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Deutschland.
Zentralbl Chir. 2015 Feb;140(1):74-82. doi: 10.1055/s-0032-1328590. Epub 2013 Aug 5.
Within the last decade, there has been a tremendous progress in understanding the molecular basis of cancer. In particular, the development and the characteristic features of cancer cells are being increasingly understood. The understanding of these molecular characteristics is mandatory for the development of novel, targeted therapeutic strategies and their integration into clinical practice. In addition, tumour genetics play a critically important role for hereditary cancer syndromes, with respect to both diagnostics and clinical decision-making. The aim of this review is to highlight general principles of tumour genetics from a visceral surgeon's point of view, although a comprehensive summary of all aspects would be beyond the scope of this article due to the complexity of the topic.
在过去十年中，我们对癌症分子基础的理解取得了巨大进展。特别是，癌细胞的发展及其特征正日益为人所知。了解这些分子特征对于开发新的靶向治疗策略并将其融入临床实践至关重要。此外，肿瘤遗传学在遗传性癌症综合征的诊断和临床决策方面都发挥着极其重要的作用。本综述的目的是从普通外科医生的角度强调肿瘤遗传学的一般原则，不过由于该主题的复杂性，全面总结所有方面超出了本文的范围。
