Coondoo Arijit, Chattopadhyay Chandan
Department of Dermatology, KPC Medical College and Hospital, Kolkata, India.
Indian J Dermatol. 2013 Jul;58(4):249-54. doi: 10.4103/0019-5154.113928.
A drug interaction is a process by which a drug or any other substance interacts with another drug and affects its activity by increasing or decreasing its effect, causing a side effect or producing a new effect unrelated to the effect of either. Interactions may be of various types-drug-drug interactions, drug-food interactions, drug-medical condition interactions, or drug-herb interactions. Interactions may occur by single or multiple mechanisms. They may occur in vivo or in vitro (pharmaceutical reactions). In vivo interactions may be further subdivided into pharmacodynamic or pharmacokinetic reactions. Topical drug interactions which may be agonistic or antagonistic may occur between two drugs applied topically or between a topical and a systemic drug. Topical drug-food interaction (for example, grape fruit juice and cyclosporine) and drug-disease interactions (for example, topical corticosteroid and aloe vera) may also occur. It is important for the dermatologist to be aware of such interactions to avoid complications of therapy in day-to-day practice.
药物相互作用是一种药物或任何其他物质与另一种药物相互作用，并通过增强或减弱其作用、引起副作用或产生与两者作用均无关的新作用来影响其活性的过程。相互作用可能有多种类型——药物-药物相互作用、药物-食物相互作用、药物-疾病状态相互作用或药物-草药相互作用。相互作用可能通过单一或多种机制发生。它们可能在体内或体外发生（药物反应）。体内相互作用可进一步细分为药效学或药代动力学反应。局部应用的两种药物之间或局部用药与全身用药之间可能发生具有激动或拮抗作用的局部药物相互作用。也可能发生局部药物-食物相互作用（例如，葡萄柚汁与环孢素）和药物-疾病相互作用（例如，局部用皮质类固醇与芦荟）。皮肤科医生了解此类相互作用对于在日常实践中避免治疗并发症很重要。
