Bushra Rabia, Aslam Nousheen, Khan Arshad Yar
Oman Med J. 2011 Mar;26(2):77-83. doi: 10.5001/omj.2011.21.
The effect of drug on a person may be different than expected because that drug interacts with another drug the person is taking (drug-drug interaction), food, beverages, dietary supplements the person is consuming (drug-nutrient/food interaction) or another disease the person has (drug-disease interaction). A drug interaction is a situation in which a substance affects the activity of a drug, i.e. the effects are increased or decreased, or they produce a new effect that neither produces on its own. These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. Regarding food-drug interactions physicians and pharmacists recognize that some foods and drugs, when taken simultaneously, can alter the body's ability to utilize a particular food or drug, or cause serious side effects. Clinically significant drug interactions, which pose potential harm to the patient, may result from changes in pharmaceutical, pharmacokinetic, or pharmacodynamic properties. Some may be taken advantage of, to the benefit of patients, but more commonly drug interactions result in adverse drug events. Therefore it is advisable for patients to follow the physician and doctors instructions to obtain maximum benefits with least food-drug interactions. The literature survey was conducted by extracting data from different review and original articles on general or specific drug interactions with food. This review gives information about various interactions between different foods and drugs and will help physicians and pharmacists prescribe drugs cautiously with only suitable food supplement to get maximum benefit for the patient.
药物对人的影响可能与预期不同，因为该药物会与患者正在服用的另一种药物（药物相互作用）、食物、饮料、膳食补充剂（药物 - 营养/食物相互作用）或患者患有的另一种疾病（药物 - 疾病相互作用）发生相互作用。药物相互作用是指一种物质影响药物活性的情况，即效果增强或减弱，或者产生一种它们自身单独都不会产生的新效果。这些相互作用可能是由于意外误用，或者是由于对相关物质中所含活性成分缺乏了解而发生的。关于食物 - 药物相互作用，医生和药剂师认识到，某些食物和药物同时服用时，会改变身体利用特定食物或药物的能力，或者导致严重的副作用。具有临床意义的药物相互作用，可能会对患者造成潜在危害，这可能是由药物制剂、药代动力学或药效学性质的变化引起的。有些相互作用可以被利用来造福患者，但更常见的是药物相互作用会导致药物不良事件。因此，患者最好遵循医生的指示，以在食物 - 药物相互作用最少的情况下获得最大益处。通过从关于与食物的一般或特定药物相互作用的不同综述和原始文章中提取数据进行了文献调查。本综述提供了关于不同食物和药物之间各种相互作用的信息，并将帮助医生和药剂师谨慎开药，只搭配合适的食物补充剂，以使患者获得最大益处。
