Gostishchev V K, Khokhlov A M, Vorobeĭchik T A, Shimanovskaia N P
Khirurgiia (Mosk). 1990 May(5):101-4.
The article discusses the biochemical mechanisms of skin destruction and ulcer formation in patients with varicosity of the lower limbs. Cathepsins A, B, C, and D were determined in the skin in various parts of the limb in 57 patients: in the lower third of the leg the activity of cathepsin D was increased by 183.8%, that of cathepsin B by 140.2%, and the activity of cathepsin B by 239%. On basis of the data obtained the authors conclude that cathepsins take part in skin destruction. Increased activity of cathepsin D plays the initiative role in this process. Cathepsin activity reduced after 14-16 day treatment with aescusan; D by 24.1%, B by 17.7%, and A by 15.4%. The authors link the effect of the treatment with the protective effect of the preparation on the lysosomal membranes.
本文讨论了下肢静脉曲张患者皮肤破坏和溃疡形成的生化机制。对57例患者肢体不同部位的皮肤进行了组织蛋白酶A、B、C和D的测定：在小腿下三分之一处，组织蛋白酶D的活性增加了183.8%，组织蛋白酶B增加了140.2%，组织蛋白酶B增加了239%。根据所得数据，作者得出结论，组织蛋白酶参与皮肤破坏。组织蛋白酶D活性增加在此过程中起主导作用。用七叶皂苷治疗14 - 16天后，组织蛋白酶活性降低：D降低24.1%，B降低17.7%，A降低15.4%。作者将治疗效果与该制剂对溶酶体膜的保护作用联系起来。
