Sethi Sameer, Ghai Babita, Sen Indu, Ram Jagat, Wig Jyotsna
Department of Anesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Paediatr Anaesth. 2013 Nov;23(11):1015-20. doi: 10.1111/pan.12227. Epub 2013 Aug 6.
General anesthesia with opioids provides good perioperative analgesia in infantile ocular surgeries but is associated with the risk of respiratory depression and postoperative emesis. This study aimed to assess the effectiveness of subtenon block for providing perioperative analgesia in infants undergoing cataract surgeries.
In this prospective, randomized, controlled, double-blinded trial, 63 infants of ASA grade I and II (1-12 months) were recruited to receive either subtenon block (Group SB) or 1 μg·kg(-1) i.v. fentanyl (Group F) after induction of anesthesia. Primary outcome was the number of infants requiring rescue analgesia during 4-h study period before discharge of the infants. Secondary outcomes assessed were CRIES pain score, incidence of oculocardiac reflex, surgical difficulty, and incidence of postoperative emesis.
The number of infants requiring rescue analgesia during 4-h study period was significantly less in Group SB (n = 6/32, 18.8%) compared to Group F (n = 14/31, 45.2%, P = 0.032). CRIES scores were significantly lower at and after 40 min compared to immediate postoperative period in Group F while these were comparable at all time intervals in Group SB. CRIES scores were significantly lower in Group SB compared to Group F at all time intervals except at 1 h. The incidence of oculocardiac reflex and the postoperative emesis were comparable in both the groups.
Subtenon block is an effective superior technique for postoperative analgesia compared to intravenous fentanyl in infants undergoing cataract surgery.
在婴儿眼科手术中,使用阿片类药物的全身麻醉可提供良好的围手术期镇痛效果,但存在呼吸抑制和术后呕吐的风险。本研究旨在评估球后阻滞在接受白内障手术的婴儿中提供围手术期镇痛的有效性。
在这项前瞻性、随机、对照、双盲试验中,招募了63例ASA I级和II级(1 - 12个月)的婴儿,在麻醉诱导后接受球后阻滞(SB组)或静脉注射1μg·kg⁻¹芬太尼(F组)。主要结局是婴儿出院前4小时研究期间需要补救镇痛的婴儿数量。评估的次要结局包括CRIES疼痛评分、眼心反射发生率、手术难度和术后呕吐发生率。
在4小时研究期间,SB组(n = 6/32,18.8%)需要补救镇痛的婴儿数量明显少于F组(n = 14/31,45.2%,P = 0.032)。F组在术后40分钟及之后的CRIES评分明显低于术后即刻,而SB组在所有时间间隔的CRIES评分相当。除1小时外,SB组在所有时间间隔的CRIES评分均明显低于F组。两组的眼心反射发生率和术后呕吐发生率相当。
在接受白内障手术的婴儿中,与静脉注射芬太尼相比,球后阻滞是一种有效的术后镇痛的优越技术。