Grigorian G G, Pogosian E Sh, Pogosian S Sh
Khirurgiia (Mosk). 1990 May(5):89-91.
An attempt is made to elaborate biochemical criteria of the depth of ischemia in atherosclerotic lesions of the lower limb arterial channel, based on the degree of manifestation and character of the metabolic changes. The study revealed increased content of toxic metabolites--middle mass molecules (MMM), hydroperoxides, and circulating immune complexes (CIC) in the blood of patients. The content of MMM and hydroperoxides correlated with the degree of limb ischemia. Determination of MMM, hydroperoxides, and CIC may help in evaluating the severity of the pathological process and solving problems of preoperative management of patients from the standpoint of prescribing extracorporeal methods of detoxification.
基于代谢变化的表现程度和特征，试图阐述下肢动脉通道动脉粥样硬化病变中缺血深度的生化标准。研究发现患者血液中有毒代谢产物——中等分子量分子（MMM）、氢过氧化物和循环免疫复合物（CIC）的含量增加。MMM和氢过氧化物的含量与肢体缺血程度相关。测定MMM、氢过氧化物和CIC有助于评估病理过程的严重程度，并从规定体外解毒方法的角度解决患者术前管理问题。
