[Evaluation of the degree of ischemia of the lower extremities in arteriosclerosis obliterans based on the levels of toxic metabolites in the blood].

An attempt is made to elaborate biochemical criteria of the depth of ischemia in atherosclerotic lesions of the lower limb arterial channel, based on the degree of manifestation and character of the metabolic changes. The study revealed increased content of toxic metabolites--middle mass molecules (MMM), hydroperoxides, and circulating immune complexes (CIC) in the blood of patients. The content of MMM and hydroperoxides correlated with the degree of limb ischemia. Determination of MMM, hydroperoxides, and CIC may help in evaluating the severity of the pathological process and solving problems of preoperative management of patients from the standpoint of prescribing extracorporeal methods of detoxification.